Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors

Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R. 2008. Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors. PNAS. 105(49), 19498–19503.

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Journal Article | Published
Author
Shinohara, Yoshiaki; Hirase, Hajime; Watanabe, Masahiko; Itakura, Makoto; Takahashi, Masami; Shigemoto, RyuichiIST Austria
Abstract
Left-right asymmetry of the brain has been studied mostly through psychological examination and functional imaging in primates, leaving its molecular and synaptic aspects largely unaddressed. Here, we show that hippocampal CA1 pyramidal cell synapses differ in size, shape, and glutamate receptor expression depending on the laterality of presynaptic origin. CA1 synapses receiving neuronal input from the right CA3 pyramidal cells are larger and have more perforated PSD and a GluR1 expression level twice as high as those receiving input from the left CA3. The synaptic density of GluR1 increases as the size of a synapse increases, whereas that of NR2B decreases because of the relatively constant NR2B expression in CA1 regardless of synapse size. Densities of other major glutamate receptor subunits show no correlation with synapse size, thus resulting in higher net expression in synapses having right input. Our study demonstrates universal left-right asymmetry of hippocampal synapses with a fundamental relationship between synaptic area and the expression of glutamate receptor subunits.
Publishing Year
Date Published
2008-12-09
Journal Title
PNAS
Volume
105
Issue
49
Page
19498 - 19503
IST-REx-ID

Cite this

Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R. Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors. PNAS. 2008;105(49):19498-19503. doi:10.1073/pnas.0807461105
Shinohara, Y., Hirase, H., Watanabe, M., Itakura, M., Takahashi, M., & Shigemoto, R. (2008). Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.0807461105
Shinohara, Yoshiaki, Hajime Hirase, Masahiko Watanabe, Makoto Itakura, Masami Takahashi, and Ryuichi Shigemoto. “Left-Right Asymmetry of the Hippocampal Synapses with Differential Subunit Allocation of Glutamate Receptors.” PNAS. National Academy of Sciences, 2008. https://doi.org/10.1073/pnas.0807461105.
Y. Shinohara, H. Hirase, M. Watanabe, M. Itakura, M. Takahashi, and R. Shigemoto, “Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors,” PNAS, vol. 105, no. 49. National Academy of Sciences, pp. 19498–19503, 2008.
Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R. 2008. Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors. PNAS. 105(49), 19498–19503.
Shinohara, Yoshiaki, et al. “Left-Right Asymmetry of the Hippocampal Synapses with Differential Subunit Allocation of Glutamate Receptors.” PNAS, vol. 105, no. 49, National Academy of Sciences, 2008, pp. 19498–503, doi:10.1073/pnas.0807461105.

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