Right isomerism of the brain in inversus viscerum mutant mice

Kawakami R, Dobi A, Shigemoto R, Ito I. 2008. Right isomerism of the brain in inversus viscerum mutant mice. PLoS One. 3(4).

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Journal Article | Published
Author
Kawakami, Ryosuke; Dobi, Alice; Shigemoto, RyuichiIST Austria ; Ito, Isao
Abstract
Left-right (L-R) asymmetry is a fundamental feature of higher-order neural function. However, the molecular basis of brain asymmetry remains unclear. We recently reported L-R asymmetry of hippocampal circuitry caused by differential allocation of N-methyl-O-aspartate receptor (NMDAR) subunit GluRε2 (NR2B) in hippocambal synapses. Using electrophysiology and immunocytochemistry, here we analyzed the hippocampal circuitry of the inversus viscerum (iv) mouse that has a randomized laterality of internal organs. The iv mouse hippocampus lacks L-R asymmetry, it exhibits right isomerism in the synaptic distribution of the ε2 subunit, irrespective of the laterality of visceral organs. This independent right isomerism of the hippocampus is the first evidence that a distinct mechanism downstream of the iv mutation generates brain asymmetry.
Publishing Year
Date Published
2008-04-16
Journal Title
PLoS One
Volume
3
Issue
4
IST-REx-ID

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Kawakami R, Dobi A, Shigemoto R, Ito I. Right isomerism of the brain in inversus viscerum mutant mice. PLoS One. 2008;3(4). doi:10.1371/journal.pone.0001945
Kawakami, R., Dobi, A., Shigemoto, R., & Ito, I. (2008). Right isomerism of the brain in inversus viscerum mutant mice. PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0001945
Kawakami, Ryosuke, Alice Dobi, Ryuichi Shigemoto, and Isao Ito. “Right Isomerism of the Brain in Inversus Viscerum Mutant Mice.” PLoS One. Public Library of Science, 2008. https://doi.org/10.1371/journal.pone.0001945.
R. Kawakami, A. Dobi, R. Shigemoto, and I. Ito, “Right isomerism of the brain in inversus viscerum mutant mice,” PLoS One, vol. 3, no. 4. Public Library of Science, 2008.
Kawakami R, Dobi A, Shigemoto R, Ito I. 2008. Right isomerism of the brain in inversus viscerum mutant mice. PLoS One. 3(4).
Kawakami, Ryosuke, et al. “Right Isomerism of the Brain in Inversus Viscerum Mutant Mice.” PLoS One, vol. 3, no. 4, Public Library of Science, 2008, doi:10.1371/journal.pone.0001945.

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