--- _id: '2673' abstract: - lang: eng text: Excitatory synaptic transmission is inhibited by G protein coupled receptors, including the adenosine A1, GABAB, and metabotropic glutamate receptor 7. These receptors are present in nerve terminals where they reduce the release of glutamate through activating signaling pathways negatively coupled to Ca2+ channels and adenylyl cyclase. However, it is not clear whether these receptors operate in distinct subpopulations of nerve terminals or if they are co-expressed in the same nerve terminals, despite the functional consequences that such distributions may have on synaptic transmission. Applying Ca2+ imaging and immunocytochemistry, we show that these three G protein coupled receptors coexist in a subpopulation of cerebrocortical nerve terminals. The three receptors share an intracellular signaling pathway through which their inhibitory responses are integrated and coactivation of these receptors produced an integrated response. Indeed, this response was highly variable, from a synergistic response at subthreshold agonist concentrations to an occluded response at high agonist concentrations. The presence of multiple receptors in a nerve terminal could be responsible for the physiological effects of neurotransmitter spillover from neighboring synapses or alternatively, the co-release of transmitters by the same nerve terminal. author: - first_name: Carolina full_name: Ladera, Carolina last_name: Ladera - first_name: María full_name: Godino, María D last_name: Godino - first_name: Ricardo full_name: Martín, Ricardo J last_name: Martín - first_name: Rafael full_name: Luján, Rafael last_name: Luján - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Francisco full_name: Ciruela, Francisco last_name: Ciruela - first_name: Magdalena full_name: Torres, Magdalena last_name: Torres - first_name: José full_name: Sánchez-Prieto, José last_name: Sánchez Prieto citation: ama: Ladera C, Godino M, Martín R, et al. The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. Journal of Neurochemistry. 2007;103(6):2314-2326. doi:10.1111/j.1471-4159.2007.04964.x apa: Ladera, C., Godino, M., Martín, R., Luján, R., Shigemoto, R., Ciruela, F., … Sánchez Prieto, J. (2007). The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. Journal of Neurochemistry. Wiley-Blackwell. https://doi.org/10.1111/j.1471-4159.2007.04964.x chicago: Ladera, Carolina, María Godino, Ricardo Martín, Rafael Luján, Ryuichi Shigemoto, Francisco Ciruela, Magdalena Torres, and José Sánchez Prieto. “ The Coexistence of Multiple Receptors in a Single Nerve Terminal Provides Evidence for Pre-Synaptic Integration.” Journal of Neurochemistry. Wiley-Blackwell, 2007. https://doi.org/10.1111/j.1471-4159.2007.04964.x. ieee: C. Ladera et al., “ The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration,” Journal of Neurochemistry, vol. 103, no. 6. Wiley-Blackwell, pp. 2314–2326, 2007. ista: Ladera C, Godino M, Martín R, Luján R, Shigemoto R, Ciruela F, Torres M, Sánchez Prieto J. 2007. The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. Journal of Neurochemistry. 103(6), 2314–2326. mla: Ladera, Carolina, et al. “ The Coexistence of Multiple Receptors in a Single Nerve Terminal Provides Evidence for Pre-Synaptic Integration.” Journal of Neurochemistry, vol. 103, no. 6, Wiley-Blackwell, 2007, pp. 2314–26, doi:10.1111/j.1471-4159.2007.04964.x. short: C. Ladera, M. Godino, R. Martín, R. Luján, R. Shigemoto, F. Ciruela, M. Torres, J. Sánchez Prieto, Journal of Neurochemistry 103 (2007) 2314–2326. date_created: 2018-12-11T11:58:59Z date_published: 2007-12-01T00:00:00Z date_updated: 2021-01-12T06:58:58Z day: '01' doi: 10.1111/j.1471-4159.2007.04964.x extern: 1 intvolume: ' 103' issue: '6' month: '12' page: 2314 - 2326 publication: Journal of Neurochemistry publication_status: published publisher: Wiley-Blackwell publist_id: '4224' quality_controlled: 0 status: public title: ' The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration' type: journal_article volume: 103 year: '2007' ...