---
_id: '2673'
abstract:
- lang: eng
text: Excitatory synaptic transmission is inhibited by G protein coupled receptors,
including the adenosine A1, GABAB, and metabotropic glutamate receptor 7. These
receptors are present in nerve terminals where they reduce the release of glutamate
through activating signaling pathways negatively coupled to Ca2+ channels and
adenylyl cyclase. However, it is not clear whether these receptors operate in
distinct subpopulations of nerve terminals or if they are co-expressed in the
same nerve terminals, despite the functional consequences that such distributions
may have on synaptic transmission. Applying Ca2+ imaging and immunocytochemistry,
we show that these three G protein coupled receptors coexist in a subpopulation
of cerebrocortical nerve terminals. The three receptors share an intracellular
signaling pathway through which their inhibitory responses are integrated and
coactivation of these receptors produced an integrated response. Indeed, this
response was highly variable, from a synergistic response at subthreshold agonist
concentrations to an occluded response at high agonist concentrations. The presence
of multiple receptors in a nerve terminal could be responsible for the physiological
effects of neurotransmitter spillover from neighboring synapses or alternatively,
the co-release of transmitters by the same nerve terminal.
author:
- first_name: Carolina
full_name: Ladera, Carolina
last_name: Ladera
- first_name: María
full_name: Godino, María D
last_name: Godino
- first_name: Ricardo
full_name: Martín, Ricardo J
last_name: Martín
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Francisco
full_name: Ciruela, Francisco
last_name: Ciruela
- first_name: Magdalena
full_name: Torres, Magdalena
last_name: Torres
- first_name: José
full_name: Sánchez-Prieto, José
last_name: Sánchez Prieto
citation:
ama: Ladera C, Godino M, Martín R, et al. The coexistence of multiple receptors
in a single nerve terminal provides evidence for pre-synaptic integration. Journal
of Neurochemistry. 2007;103(6):2314-2326. doi:10.1111/j.1471-4159.2007.04964.x
apa: Ladera, C., Godino, M., Martín, R., Luján, R., Shigemoto, R., Ciruela, F.,
… Sánchez Prieto, J. (2007). The coexistence of multiple receptors in a single
nerve terminal provides evidence for pre-synaptic integration. Journal of Neurochemistry.
Wiley-Blackwell. https://doi.org/10.1111/j.1471-4159.2007.04964.x
chicago: Ladera, Carolina, María Godino, Ricardo Martín, Rafael Luján, Ryuichi Shigemoto,
Francisco Ciruela, Magdalena Torres, and José Sánchez Prieto. “ The Coexistence
of Multiple Receptors in a Single Nerve Terminal Provides Evidence for Pre-Synaptic
Integration.” Journal of Neurochemistry. Wiley-Blackwell, 2007. https://doi.org/10.1111/j.1471-4159.2007.04964.x.
ieee: C. Ladera et al., “ The coexistence of multiple receptors in a single
nerve terminal provides evidence for pre-synaptic integration,” Journal of
Neurochemistry, vol. 103, no. 6. Wiley-Blackwell, pp. 2314–2326, 2007.
ista: Ladera C, Godino M, Martín R, Luján R, Shigemoto R, Ciruela F, Torres M, Sánchez
Prieto J. 2007. The coexistence of multiple receptors in a single nerve terminal
provides evidence for pre-synaptic integration. Journal of Neurochemistry. 103(6),
2314–2326.
mla: Ladera, Carolina, et al. “ The Coexistence of Multiple Receptors in a Single
Nerve Terminal Provides Evidence for Pre-Synaptic Integration.” Journal of
Neurochemistry, vol. 103, no. 6, Wiley-Blackwell, 2007, pp. 2314–26, doi:10.1111/j.1471-4159.2007.04964.x.
short: C. Ladera, M. Godino, R. Martín, R. Luján, R. Shigemoto, F. Ciruela, M. Torres,
J. Sánchez Prieto, Journal of Neurochemistry 103 (2007) 2314–2326.
date_created: 2018-12-11T11:58:59Z
date_published: 2007-12-01T00:00:00Z
date_updated: 2021-01-12T06:58:58Z
day: '01'
doi: 10.1111/j.1471-4159.2007.04964.x
extern: 1
intvolume: ' 103'
issue: '6'
month: '12'
page: 2314 - 2326
publication: Journal of Neurochemistry
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4224'
quality_controlled: 0
status: public
title: ' The coexistence of multiple receptors in a single nerve terminal provides
evidence for pre-synaptic integration'
type: journal_article
volume: 103
year: '2007'
...