Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation

Bender R, Kirschstein T, Kretz O, Brewster A, Richichi C, Rüschenschmidt C, Shigemoto R, Beck H, Frotscher M, Baram T. 2007. Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation. Journal of Neuroscience. 27(17), 4697–4706.

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Author
Bender, Roland A; Kirschstein, Timo; Kretz, Oliver; Brewster, Amy L; Richichi, Cristina; Rüschenschmidt, Christiane; Shigemoto, RyuichiIST Austria ; Beck,Heinz; Frotscher, Michael; Baram, Tallie Z
Abstract
Increasing evidence supports roles for the current mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, I h, in hippocampal maturation and specifically in the evolving changes of intrinsic properties as well as network responses of hippocampal neurons. Here, we describe a novel developmental plasticity of HCN channel expression in axonal and presynaptic compartments: HCN1 channels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway) of immature rats, where they modulated synaptic efficacy. However, presynaptic expression and functions of the channels disappeared with maturation. This was a result of altered channel transport to the axons, because HCN1 mRNA and protein levels in entorhinal cortex neurons, where the perforant path axons originate, were stable through adulthood. Blocking action potential firing in vitro increased presynaptic expression of HCN1 channels in the perforant path, suggesting that network activity contributed to regulating this expression. These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic I h in hippocampal maturation.
Publishing Year
Date Published
2007-04-25
Journal Title
Journal of Neuroscience
Volume
27
Issue
17
Page
4697 - 4706
IST-REx-ID

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Bender R, Kirschstein T, Kretz O, et al. Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation. Journal of Neuroscience. 2007;27(17):4697-4706. doi:10.1523/JNEUROSCI.4699-06.2007
Bender, R., Kirschstein, T., Kretz, O., Brewster, A., Richichi, C., Rüschenschmidt, C., … Baram, T. (2007). Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.4699-06.2007
Bender, Roland, Timo Kirschstein, Oliver Kretz, Amy Brewster, Cristina Richichi, Christiane Rüschenschmidt, Ryuichi Shigemoto, Heinz Beck, Michael Frotscher, and Tallie Baram. “Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation.” Journal of Neuroscience. Society for Neuroscience, 2007. https://doi.org/10.1523/JNEUROSCI.4699-06.2007.
R. Bender et al., “Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation,” Journal of Neuroscience, vol. 27, no. 17. Society for Neuroscience, pp. 4697–4706, 2007.
Bender R, Kirschstein T, Kretz O, Brewster A, Richichi C, Rüschenschmidt C, Shigemoto R, Beck H, Frotscher M, Baram T. 2007. Localization of HCN1 channels to presynaptic compartments: Novel plasticity that may contribute to hippocampal maturation. Journal of Neuroscience. 27(17), 4697–4706.
Bender, Roland, et al. “Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation.” Journal of Neuroscience, vol. 27, no. 17, Society for Neuroscience, 2007, pp. 4697–706, doi:10.1523/JNEUROSCI.4699-06.2007.

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