High-resolution quantitative visualization of glutamate and GABA receptors at central synapses

Masugi Tokita M, Shigemoto R. 2007. High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. Current Opinion in Neurobiology. 17(3), 387–393.

Download
No fulltext has been uploaded. References only!

Book Review | Published
Author
Masugi-Tokita, Miwako; Shigemoto, RyuichiIST Austria
Abstract
Glutamate and GABA are the main transmitters in the central nervous system and their effects are mediated by ionotropic and metabotropic receptors. Immunogold electron microscopy has revealed the quantitative localization of these receptors at 20-30 nm resolution. SDS-digested freeze-fracture replica labeling (SDS-FRL), a newly developed immunogold method, provides an accurate estimate of molecule numbers. Here, we summarize the recent advances in quantitative receptor localization, including use of SDS-FRL analyses to determine numbers of AMPA-type glutamate receptors in the cerebellum. The two-dimensional view and high sensitivity of SDS-FRL have revealed small, irregularly shaped AMPA receptor clusters within cerebellar synapses.
Publishing Year
Date Published
2007-06-01
Journal Title
Current Opinion in Neurobiology
Volume
17
Issue
3
Page
387 - 393
IST-REx-ID

Cite this

Masugi Tokita M, Shigemoto R. High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. Current Opinion in Neurobiology. 2007;17(3):387-393. doi:10.1016/j.conb.2007.04.012
Masugi Tokita, M., & Shigemoto, R. (2007). High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. Current Opinion in Neurobiology. Elsevier. https://doi.org/10.1016/j.conb.2007.04.012
Masugi Tokita, Miwako, and Ryuichi Shigemoto. “High-Resolution Quantitative Visualization of Glutamate and GABA Receptors at Central Synapses.” Current Opinion in Neurobiology. Elsevier, 2007. https://doi.org/10.1016/j.conb.2007.04.012.
M. Masugi Tokita and R. Shigemoto, “High-resolution quantitative visualization of glutamate and GABA receptors at central synapses,” Current Opinion in Neurobiology, vol. 17, no. 3. Elsevier, pp. 387–393, 2007.
Masugi Tokita M, Shigemoto R. 2007. High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. Current Opinion in Neurobiology. 17(3), 387–393.
Masugi Tokita, Miwako, and Ryuichi Shigemoto. “High-Resolution Quantitative Visualization of Glutamate and GABA Receptors at Central Synapses.” Current Opinion in Neurobiology, vol. 17, no. 3, Elsevier, 2007, pp. 387–93, doi:10.1016/j.conb.2007.04.012.

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar