---
_id: '2665'
abstract:
- lang: eng
text: Substance P (SP) is known to be a peptide that facilitates epileptic activity
of principal cells in the hippocampus. Paradoxically, in other models, it was
found to be protective against seizures by activating substance P receptor (SPR)-expressing
interneurons. Thus, these cells appear to play an important role in the generation
and regulation of epileptic seizures. The number, distribution, morphological
features and input characteristics of SPR-immunoreactive cells were analyzed in
surgically removed hippocampi of 28 temporal lobe epileptic patients and eight
control hippocampi in order to examine their changes in epileptic tissues. SPR
is expressed in a subset of inhibitory cells in the control human hippocampus,
they are multipolar interneurons with smooth dendrites, present in all hippocampal
subfields. This cell population is considerably different from SPR-positive cells
of the rat hippocampus. The CA1 (cornu Ammonis subfield 1) region was chosen for
the detailed morphological analysis of the SPR-immunoreactive cells because of
its extreme vulnerability in epilepsy. The presence of various neurochemical markers
identifies functionally distinct interneuron types, such as those responsible
for perisomatic, dendritic or interneuron-selective inhibition. We found considerable
colocalization of SPR with calbindin but not with parvalbumin, calretinin, cholecystokinin
and somatostatin, therefore we suppose that SPR-positive cells participate mainly
in dendritic inhibition. In the non-sclerotic CA1 region they are mainly preserved,
whereas their number is decreased in the sclerotic cases. In the epileptic samples
their morphology is considerably altered, they possessed more dendritic branches,
which often became beaded. Analyses of synaptic coverage revealed that the ratio
of symmetric synaptic input of SPR-immunoreactive cells has increased in epileptic
samples. Our results suggest that SPR-positive cells are preserved while principal
cells are present in the CA1 region, but show reactive changes in epilepsy including
intense branching and growth of their dendritic arborization.
author:
- first_name: Kinga
full_name: Tóth, Kinga
last_name: Tóth
- first_name: Lucia
full_name: Wittner, Lucia
last_name: Wittner
- first_name: Z
full_name: Urbán, Z
last_name: Urbán
- first_name: Werner
full_name: Doyle, Werner K
last_name: Doyle
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Tamás
full_name: Freund, Tamás F
last_name: Freund
- first_name: Zsófia
full_name: Maglóczky, Zsófia
last_name: Maglóczky
citation:
ama: Tóth K, Wittner L, Urbán Z, et al. Morphology and synaptic input of substance
P receptor-immunoreactive interneurons in control and epileptic human hippocampus.
Neuroscience. 2007;144(2):495-508. doi:10.1016/j.neuroscience.2006.09.039
apa: Tóth, K., Wittner, L., Urbán, Z., Doyle, W., Buzsáki, G., Shigemoto, R., …
Maglóczky, Z. (2007). Morphology and synaptic input of substance P receptor-immunoreactive
interneurons in control and epileptic human hippocampus. Neuroscience.
Elsevier. https://doi.org/10.1016/j.neuroscience.2006.09.039
chicago: Tóth, Kinga, Lucia Wittner, Z Urbán, Werner Doyle, György Buzsáki, Ryuichi
Shigemoto, Tamás Freund, and Zsófia Maglóczky. “Morphology and Synaptic Input
of Substance P Receptor-Immunoreactive Interneurons in Control and Epileptic Human
Hippocampus.” Neuroscience. Elsevier, 2007. https://doi.org/10.1016/j.neuroscience.2006.09.039.
ieee: K. Tóth et al., “Morphology and synaptic input of substance P receptor-immunoreactive
interneurons in control and epileptic human hippocampus,” Neuroscience,
vol. 144, no. 2. Elsevier, pp. 495–508, 2007.
ista: Tóth K, Wittner L, Urbán Z, Doyle W, Buzsáki G, Shigemoto R, Freund T, Maglóczky
Z. 2007. Morphology and synaptic input of substance P receptor-immunoreactive
interneurons in control and epileptic human hippocampus. Neuroscience. 144(2),
495–508.
mla: Tóth, Kinga, et al. “Morphology and Synaptic Input of Substance P Receptor-Immunoreactive
Interneurons in Control and Epileptic Human Hippocampus.” Neuroscience,
vol. 144, no. 2, Elsevier, 2007, pp. 495–508, doi:10.1016/j.neuroscience.2006.09.039.
short: K. Tóth, L. Wittner, Z. Urbán, W. Doyle, G. Buzsáki, R. Shigemoto, T. Freund,
Z. Maglóczky, Neuroscience 144 (2007) 495–508.
date_created: 2018-12-11T11:58:57Z
date_published: 2007-01-19T00:00:00Z
date_updated: 2021-01-12T06:58:55Z
day: '19'
doi: 10.1016/j.neuroscience.2006.09.039
extern: 1
intvolume: ' 144'
issue: '2'
month: '01'
page: 495 - 508
publication: Neuroscience
publication_status: published
publisher: Elsevier
publist_id: '4232'
quality_controlled: 0
status: public
title: Morphology and synaptic input of substance P receptor-immunoreactive interneurons
in control and epileptic human hippocampus
type: journal_article
volume: 144
year: '2007'
...