--- _id: '2665' abstract: - lang: eng text: Substance P (SP) is known to be a peptide that facilitates epileptic activity of principal cells in the hippocampus. Paradoxically, in other models, it was found to be protective against seizures by activating substance P receptor (SPR)-expressing interneurons. Thus, these cells appear to play an important role in the generation and regulation of epileptic seizures. The number, distribution, morphological features and input characteristics of SPR-immunoreactive cells were analyzed in surgically removed hippocampi of 28 temporal lobe epileptic patients and eight control hippocampi in order to examine their changes in epileptic tissues. SPR is expressed in a subset of inhibitory cells in the control human hippocampus, they are multipolar interneurons with smooth dendrites, present in all hippocampal subfields. This cell population is considerably different from SPR-positive cells of the rat hippocampus. The CA1 (cornu Ammonis subfield 1) region was chosen for the detailed morphological analysis of the SPR-immunoreactive cells because of its extreme vulnerability in epilepsy. The presence of various neurochemical markers identifies functionally distinct interneuron types, such as those responsible for perisomatic, dendritic or interneuron-selective inhibition. We found considerable colocalization of SPR with calbindin but not with parvalbumin, calretinin, cholecystokinin and somatostatin, therefore we suppose that SPR-positive cells participate mainly in dendritic inhibition. In the non-sclerotic CA1 region they are mainly preserved, whereas their number is decreased in the sclerotic cases. In the epileptic samples their morphology is considerably altered, they possessed more dendritic branches, which often became beaded. Analyses of synaptic coverage revealed that the ratio of symmetric synaptic input of SPR-immunoreactive cells has increased in epileptic samples. Our results suggest that SPR-positive cells are preserved while principal cells are present in the CA1 region, but show reactive changes in epilepsy including intense branching and growth of their dendritic arborization. author: - first_name: Kinga full_name: Tóth, Kinga last_name: Tóth - first_name: Lucia full_name: Wittner, Lucia last_name: Wittner - first_name: Z full_name: Urbán, Z last_name: Urbán - first_name: Werner full_name: Doyle, Werner K last_name: Doyle - first_name: György full_name: Buzsáki, György last_name: Buzsáki - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Tamás full_name: Freund, Tamás F last_name: Freund - first_name: Zsófia full_name: Maglóczky, Zsófia last_name: Maglóczky citation: ama: Tóth K, Wittner L, Urbán Z, et al. Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus. Neuroscience. 2007;144(2):495-508. doi:10.1016/j.neuroscience.2006.09.039 apa: Tóth, K., Wittner, L., Urbán, Z., Doyle, W., Buzsáki, G., Shigemoto, R., … Maglóczky, Z. (2007). Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus. Neuroscience. Elsevier. https://doi.org/10.1016/j.neuroscience.2006.09.039 chicago: Tóth, Kinga, Lucia Wittner, Z Urbán, Werner Doyle, György Buzsáki, Ryuichi Shigemoto, Tamás Freund, and Zsófia Maglóczky. “Morphology and Synaptic Input of Substance P Receptor-Immunoreactive Interneurons in Control and Epileptic Human Hippocampus.” Neuroscience. Elsevier, 2007. https://doi.org/10.1016/j.neuroscience.2006.09.039. ieee: K. Tóth et al., “Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus,” Neuroscience, vol. 144, no. 2. Elsevier, pp. 495–508, 2007. ista: Tóth K, Wittner L, Urbán Z, Doyle W, Buzsáki G, Shigemoto R, Freund T, Maglóczky Z. 2007. Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus. Neuroscience. 144(2), 495–508. mla: Tóth, Kinga, et al. “Morphology and Synaptic Input of Substance P Receptor-Immunoreactive Interneurons in Control and Epileptic Human Hippocampus.” Neuroscience, vol. 144, no. 2, Elsevier, 2007, pp. 495–508, doi:10.1016/j.neuroscience.2006.09.039. short: K. Tóth, L. Wittner, Z. Urbán, W. Doyle, G. Buzsáki, R. Shigemoto, T. Freund, Z. Maglóczky, Neuroscience 144 (2007) 495–508. date_created: 2018-12-11T11:58:57Z date_published: 2007-01-19T00:00:00Z date_updated: 2021-01-12T06:58:55Z day: '19' doi: 10.1016/j.neuroscience.2006.09.039 extern: 1 intvolume: ' 144' issue: '2' month: '01' page: 495 - 508 publication: Neuroscience publication_status: published publisher: Elsevier publist_id: '4232' quality_controlled: 0 status: public title: Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus type: journal_article volume: 144 year: '2007' ...