--- _id: '2660' abstract: - lang: eng text: Pavlovian fear conditioning, a simple form of associative learning, is thought to involve the induction of associative, NMDA receptor-dependent long-term potentiation (LTP) in the lateral amygdala. Using a combined genetic and electrophysiological approach, we show here that lack of a specific GABAB receptor subtype, GABAB(1a,2), unmasks a nonassociative, NMDA receptor-independent form of presynaptic LTP at cortico-amygdala afferents. Moreover, the level of presynaptic GABA B(1a,2) receptor activation, and hence the balance between associative and nonassociative forms of LTP, can be dynamically modulated by local inhibitory activity. At the behavioral level, genetic loss of GABA B(1a) results in a generalization of conditioned fear to nonconditioned stimuli. Our findings indicate that presynaptic inhibition through GABAB(1a,2) receptors serves as an activity-dependent constraint on the induction of homosynaptic plasticity, which may be important to prevent the generalization of conditioned fear. author: - first_name: Hamdy full_name: Shaban, Hamdy last_name: Shaban - first_name: Yann full_name: Humeau, Yann last_name: Humeau - first_name: Cyril full_name: Herry, Cyril last_name: Herry - first_name: Guillaume full_name: Cassasus, Guillaume last_name: Cassasus - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Stéphane full_name: Ciocchi, Stéphane last_name: Ciocchi - first_name: Samuel full_name: Barbieri, Samuel last_name: Barbieri - first_name: Herman full_name: Van Der Putten, Herman V last_name: Van Der Putten - first_name: Klemens full_name: Kaupmann, Klemens last_name: Kaupmann - first_name: Bernhard full_name: Bettler, Bernhard last_name: Bettler - first_name: Andreas full_name: Lüthi, Andreas last_name: Lüthi citation: ama: Shaban H, Humeau Y, Herry C, et al. Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nature Neuroscience. 2006;9(8):1028-1035. doi:10.1038/nn1732 apa: Shaban, H., Humeau, Y., Herry, C., Cassasus, G., Shigemoto, R., Ciocchi, S., … Lüthi, A. (2006). Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn1732 chicago: Shaban, Hamdy, Yann Humeau, Cyril Herry, Guillaume Cassasus, Ryuichi Shigemoto, Stéphane Ciocchi, Samuel Barbieri, et al. “Generalization of Amygdala LTP and Conditioned Fear in the Absence of Presynaptic Inhibition.” Nature Neuroscience. Nature Publishing Group, 2006. https://doi.org/10.1038/nn1732. ieee: H. Shaban et al., “Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition,” Nature Neuroscience, vol. 9, no. 8. Nature Publishing Group, pp. 1028–1035, 2006. ista: Shaban H, Humeau Y, Herry C, Cassasus G, Shigemoto R, Ciocchi S, Barbieri S, Van Der Putten H, Kaupmann K, Bettler B, Lüthi A. 2006. Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nature Neuroscience. 9(8), 1028–1035. mla: Shaban, Hamdy, et al. “Generalization of Amygdala LTP and Conditioned Fear in the Absence of Presynaptic Inhibition.” Nature Neuroscience, vol. 9, no. 8, Nature Publishing Group, 2006, pp. 1028–35, doi:10.1038/nn1732. short: H. Shaban, Y. Humeau, C. Herry, G. Cassasus, R. Shigemoto, S. Ciocchi, S. Barbieri, H. Van Der Putten, K. Kaupmann, B. Bettler, A. Lüthi, Nature Neuroscience 9 (2006) 1028–1035. date_created: 2018-12-11T11:58:55Z date_published: 2006-08-01T00:00:00Z date_updated: 2021-01-12T06:58:53Z day: '01' doi: 10.1038/nn1732 extern: 1 intvolume: ' 9' issue: '8' month: '08' page: 1028 - 1035 publication: Nature Neuroscience publication_status: published publisher: Nature Publishing Group publist_id: '4236' quality_controlled: 0 status: public title: Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition type: journal_article volume: 9 year: '2006' ...