---
_id: '2660'
abstract:
- lang: eng
text: Pavlovian fear conditioning, a simple form of associative learning, is thought
to involve the induction of associative, NMDA receptor-dependent long-term potentiation
(LTP) in the lateral amygdala. Using a combined genetic and electrophysiological
approach, we show here that lack of a specific GABAB receptor subtype, GABAB(1a,2),
unmasks a nonassociative, NMDA receptor-independent form of presynaptic LTP at
cortico-amygdala afferents. Moreover, the level of presynaptic GABA B(1a,2) receptor
activation, and hence the balance between associative and nonassociative forms
of LTP, can be dynamically modulated by local inhibitory activity. At the behavioral
level, genetic loss of GABA B(1a) results in a generalization of conditioned fear
to nonconditioned stimuli. Our findings indicate that presynaptic inhibition through
GABAB(1a,2) receptors serves as an activity-dependent constraint on the induction
of homosynaptic plasticity, which may be important to prevent the generalization
of conditioned fear.
author:
- first_name: Hamdy
full_name: Shaban, Hamdy
last_name: Shaban
- first_name: Yann
full_name: Humeau, Yann
last_name: Humeau
- first_name: Cyril
full_name: Herry, Cyril
last_name: Herry
- first_name: Guillaume
full_name: Cassasus, Guillaume
last_name: Cassasus
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Stéphane
full_name: Ciocchi, Stéphane
last_name: Ciocchi
- first_name: Samuel
full_name: Barbieri, Samuel
last_name: Barbieri
- first_name: Herman
full_name: Van Der Putten, Herman V
last_name: Van Der Putten
- first_name: Klemens
full_name: Kaupmann, Klemens
last_name: Kaupmann
- first_name: Bernhard
full_name: Bettler, Bernhard
last_name: Bettler
- first_name: Andreas
full_name: Lüthi, Andreas
last_name: Lüthi
citation:
ama: Shaban H, Humeau Y, Herry C, et al. Generalization of amygdala LTP and conditioned
fear in the absence of presynaptic inhibition. Nature Neuroscience. 2006;9(8):1028-1035.
doi:10.1038/nn1732
apa: Shaban, H., Humeau, Y., Herry, C., Cassasus, G., Shigemoto, R., Ciocchi, S.,
… Lüthi, A. (2006). Generalization of amygdala LTP and conditioned fear in the
absence of presynaptic inhibition. Nature Neuroscience. Nature Publishing
Group. https://doi.org/10.1038/nn1732
chicago: Shaban, Hamdy, Yann Humeau, Cyril Herry, Guillaume Cassasus, Ryuichi Shigemoto,
Stéphane Ciocchi, Samuel Barbieri, et al. “Generalization of Amygdala LTP and
Conditioned Fear in the Absence of Presynaptic Inhibition.” Nature Neuroscience.
Nature Publishing Group, 2006. https://doi.org/10.1038/nn1732.
ieee: H. Shaban et al., “Generalization of amygdala LTP and conditioned fear
in the absence of presynaptic inhibition,” Nature Neuroscience, vol. 9,
no. 8. Nature Publishing Group, pp. 1028–1035, 2006.
ista: Shaban H, Humeau Y, Herry C, Cassasus G, Shigemoto R, Ciocchi S, Barbieri
S, Van Der Putten H, Kaupmann K, Bettler B, Lüthi A. 2006. Generalization of amygdala
LTP and conditioned fear in the absence of presynaptic inhibition. Nature Neuroscience.
9(8), 1028–1035.
mla: Shaban, Hamdy, et al. “Generalization of Amygdala LTP and Conditioned Fear
in the Absence of Presynaptic Inhibition.” Nature Neuroscience, vol. 9,
no. 8, Nature Publishing Group, 2006, pp. 1028–35, doi:10.1038/nn1732.
short: H. Shaban, Y. Humeau, C. Herry, G. Cassasus, R. Shigemoto, S. Ciocchi, S.
Barbieri, H. Van Der Putten, K. Kaupmann, B. Bettler, A. Lüthi, Nature Neuroscience
9 (2006) 1028–1035.
date_created: 2018-12-11T11:58:55Z
date_published: 2006-08-01T00:00:00Z
date_updated: 2021-01-12T06:58:53Z
day: '01'
doi: 10.1038/nn1732
extern: 1
intvolume: ' 9'
issue: '8'
month: '08'
page: 1028 - 1035
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '4236'
quality_controlled: 0
status: public
title: Generalization of amygdala LTP and conditioned fear in the absence of presynaptic
inhibition
type: journal_article
volume: 9
year: '2006'
...