--- res: bibo_abstract: - Pavlovian fear conditioning, a simple form of associative learning, is thought to involve the induction of associative, NMDA receptor-dependent long-term potentiation (LTP) in the lateral amygdala. Using a combined genetic and electrophysiological approach, we show here that lack of a specific GABAB receptor subtype, GABAB(1a,2), unmasks a nonassociative, NMDA receptor-independent form of presynaptic LTP at cortico-amygdala afferents. Moreover, the level of presynaptic GABA B(1a,2) receptor activation, and hence the balance between associative and nonassociative forms of LTP, can be dynamically modulated by local inhibitory activity. At the behavioral level, genetic loss of GABA B(1a) results in a generalization of conditioned fear to nonconditioned stimuli. Our findings indicate that presynaptic inhibition through GABAB(1a,2) receptors serves as an activity-dependent constraint on the induction of homosynaptic plasticity, which may be important to prevent the generalization of conditioned fear.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Hamdy foaf_name: Shaban, Hamdy foaf_surname: Shaban - foaf_Person: foaf_givenName: Yann foaf_name: Humeau, Yann foaf_surname: Humeau - foaf_Person: foaf_givenName: Cyril foaf_name: Herry, Cyril foaf_surname: Herry - foaf_Person: foaf_givenName: Guillaume foaf_name: Cassasus, Guillaume foaf_surname: Cassasus - foaf_Person: foaf_givenName: Ryuichi foaf_name: Ryuichi Shigemoto foaf_surname: Shigemoto foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-8761-9444 - foaf_Person: foaf_givenName: Stéphane foaf_name: Ciocchi, Stéphane foaf_surname: Ciocchi - foaf_Person: foaf_givenName: Samuel foaf_name: Barbieri, Samuel foaf_surname: Barbieri - foaf_Person: foaf_givenName: Herman foaf_name: Van Der Putten, Herman V foaf_surname: Van Der Putten - foaf_Person: foaf_givenName: Klemens foaf_name: Kaupmann, Klemens foaf_surname: Kaupmann - foaf_Person: foaf_givenName: Bernhard foaf_name: Bettler, Bernhard foaf_surname: Bettler - foaf_Person: foaf_givenName: Andreas foaf_name: Lüthi, Andreas foaf_surname: Lüthi bibo_doi: 10.1038/nn1732 bibo_issue: '8' bibo_volume: 9 dct_date: 2006^xs_gYear dct_publisher: Nature Publishing Group@ dct_title: Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition@ ...