Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus

F. Ferraguti, T. Klausberger, P. Cobden, A. Baude, J. Roberts, P. Szűcs, A. Kinoshita, R. Shigemoto, P. Somogyi, Y. Dalezios, Journal of Neuroscience 25 (2005) 10520–10536.

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Author
Ferraguti, Francesco; Klausberger,Thomas; Cobden, Philip M; Baude, Agnès; Roberts, John D; Szűcs, Péter; Kinoshita, Ayae; Shigemoto, RyuichiIST Austria ; Somogyi, Péter; Dalezios, Yannis
Abstract
Presynaptic metabotropic glutamate receptors (mGluRs) show a highly selective expression and subcellular location in nerve terminals modulating neurotransmitter release. We have demonstrated that alternatively spliced variants of mGluR8, mGluR8a and mGluR8b, have an overlapping distribution in the hippocampus, and besides perforant path terminals, they are expressed in the presynaptic active zone of boutons making synapses selectively with several types of GABAergic interneurons, primarily in the stratum oriens. Boutons labeled for mGluR8 formed either type I or type II synapses, and the latter were GABAergic. Some mGluR8-positive boutons also expressed mGluR7 or vasoactive intestinal polypeptide. Interneurons strongly immunopositive for the muscarinic M2 or the mGlu1 receptors were the primary targets of mGluR8-containing terminals in the stratum oriens, but only neurochemically distinct subsets were innervated by mGluR8-enriched terminals. The majority of M2-positive neurons were mGluR8 innervated, but a minority, which expresses somatostatin, was not. Rare neurons coexpressing calretinin and M2 were consistently targeted by mGluR8-positive boutons. In vivo recording and labeling of an mGluR8-decorated and strongly M2-positive interneuron revealed a trilaminar cell with complex spike bursts during theta oscillations and strong discharge during sharp wave/ripple events. The trilaminar cell had a large projection from the CA1 area to the subiculum and a preferential innervation of interneurons in the CA1 area in addition to pyramidal cell somata and dendrites. The postsynaptic interneuron type-specific expression of the high-efficacy presynaptic mGluR8 in both putative glutamatergic and in identified GABAergic terminals predicts a role in adjusting the activity of interneurons depending on the level of network activity.
Publishing Year
Date Published
2005-11-09
Journal Title
Journal of Neuroscience
Volume
25
Issue
45
Page
10520 - 10536
IST-REx-ID

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Ferraguti F, Klausberger T, Cobden P, et al. Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. Journal of Neuroscience. 2005;25(45):10520-10536. doi:10.1523/JNEUROSCI.2547-05.2005
Ferraguti, F., Klausberger, T., Cobden, P., Baude, A., Roberts, J., Szűcs, P., … Dalezios, Y. (2005). Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. Journal of Neuroscience, 25(45), 10520–10536. https://doi.org/10.1523/JNEUROSCI.2547-05.2005
Ferraguti, Francesco, Thomas Klausberger, Philip Cobden, Agnès Baude, John Roberts, Péter Szűcs, Ayae Kinoshita, Ryuichi Shigemoto, Péter Somogyi, and Yannis Dalezios. “ Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus.” Journal of Neuroscience 25, no. 45 (2005): 10520–36. https://doi.org/10.1523/JNEUROSCI.2547-05.2005.
F. Ferraguti et al., “ Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus,” Journal of Neuroscience, vol. 25, no. 45, pp. 10520–10536, 2005.
Ferraguti F, Klausberger T, Cobden P, Baude A, Roberts J, Szűcs P, Kinoshita A, Shigemoto R, Somogyi P, Dalezios Y. 2005. Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. Journal of Neuroscience. 25(45), 10520–10536.
Ferraguti, Francesco, et al. “ Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus.” Journal of Neuroscience, vol. 25, no. 45, Society for Neuroscience, 2005, pp. 10520–36, doi:10.1523/JNEUROSCI.2547-05.2005.

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