[{"_id":"2641","type":"journal_article","status":"public","dini_type":"doc-type:article","citation":{"chicago":"Kang, Youngnam, Takuya Notomi, Mitsuru Saito, Wei Zhang, and Ryuichi Shigemoto. “Bidirectional Interactions between H-Channels and Na+-K + Pumps in Mesencephalic Trigeminal Neurons.” Journal of Neuroscience. Society for Neuroscience, 2004. https://doi.org/10.1523/JNEUROSCI.5641-03.2004.","ista":"Kang Y, Notomi T, Saito M, Zhang W, Shigemoto R. 2004. Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons. Journal of Neuroscience. 24(14), 3694–3702.","mla":"Kang, Youngnam, et al. “Bidirectional Interactions between H-Channels and Na+-K + Pumps in Mesencephalic Trigeminal Neurons.” Journal of Neuroscience, vol. 24, no. 14, Society for Neuroscience, 2004, pp. 3694–702, doi:10.1523/JNEUROSCI.5641-03.2004.","apa":"Kang, Y., Notomi, T., Saito, M., Zhang, W., & Shigemoto, R. (2004). Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.5641-03.2004","ieee":"Y. Kang, T. Notomi, M. Saito, W. Zhang, and R. Shigemoto, “Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons,” Journal of Neuroscience, vol. 24, no. 14. Society for Neuroscience, pp. 3694–3702, 2004.","short":"Y. Kang, T. Notomi, M. Saito, W. Zhang, R. Shigemoto, Journal of Neuroscience 24 (2004) 3694–3702."},"date_updated":"2021-01-12T06:58:45Z","extern":1,"author":[{"first_name":"Youngnam","last_name":"Kang"},{"last_name":"Notomi","first_name":"Takuya"},{"first_name":"Mitsuru","last_name":"Saito"},{"last_name":"Zhang","first_name":"Wei"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"4257","abstract":[{"lang":"eng"}],"quality_controlled":0,"month":"04","intvolume":" 24","publication_status":"published","day":"07","publication":"Journal of Neuroscience","dc":{"rights":["info:eu-repo/semantics/closedAccess"],"creator":["Kang, Youngnam","Notomi, Takuya","Saito, Mitsuru","Zhang, Wei","Ryuichi Shigemoto"],"title":["Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons"],"description":["The Na+-K+ pump current (Ip) and the h-current (Ih) flowing through hyperpolarization-activated channels (h-channels) participate in generating the resting potential. These two currents are thought to be produced independently. We show here bidirectional interactions between Na+-K+ pumps and h-channels in mesencephalic trigeminal neurons. Activation of Ih leads to the generation of two types of ouabain-sensitive Ip with temporal profiles similar to those of instantaneous and slow components of I h, presumably reflecting Na+ transients in a restricted cellular space. Moreover, the Ip activated by instantaneous I h can facilitate the subsequent activation of slow Ih. Such counteractive and cooperative interactions were also disclosed by replacing extracellular Na+ with Li+, which is permeant through h-channels but does not stimulate the Na+-K+ pump as strongly as Na+ ions. These observations indicate that the interactions are bidirectional and mediated by Na+ ions. Also after substitution of extracellular Na+ with Li+, the tail Ih was reduced markedly despite an enhancement of Ih itself, attributable to a negative shift of the reversal potential for I h presumably caused by intracellular accumulation of Li+ ions. This suggests the presence of a microdomain where the interactions can take place. Thus, the bidirectional interactions between Na+-K + pumps and h-channels are likely to be mediated by Na+ microdomain. Consistent with these findings, hyperpolarization-activated and cyclic nucleotide-modulated subunits (HCN1/2) and the Na+-K + pump α3 isoform were colocalized in plasma membrane of mesencephalic trigeminal neurons having numerous spines."],"identifier":["https://research-explorer.ista.ac.at/record/2641"],"relation":["info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.5641-03.2004"],"source":["Kang Y, Notomi T, Saito M, Zhang W, Shigemoto R. Bidirectional interactions between H-channels and Na+-K + pumps in mesencephalic trigeminal neurons. Journal of Neuroscience. 2004;24(14):3694-3702. doi:10.1523/JNEUROSCI.5641-03.2004"],"type":["info:eu-repo/semantics/article","doc-type:article","text","http://purl.org/coar/resource_type/c_6501"],"publisher":["Society for Neuroscience"],"date":["2004"]},"uri_base":"https://research-explorer.ista.ac.at","page":"3694 - 3702","volume":24,"date_published":"2004-04-07T00:00:00Z","issue":"14","date_created":"2018-12-11T11:58:49Z"}]