{"citation":{"mla":"Higashida, Haruhiro, et al. “Subtype-Specific Coupling with ADP-Ribosyl Cyclase of Metabotropic Glutamate Receptors in Retina, Cervical Superior Ganglion and NG108-15 Cells.” <i>Journal of Neurochemistry</i>, vol. 85, no. 5, Wiley-Blackwell, 2003, pp. 1148–58, doi:<a href=\"https://doi.org/10.1046/j.1471-4159.2003.01751.x\">10.1046/j.1471-4159.2003.01751.x</a>.","ama":"Higashida H, Zhang J, Mochida S, et al. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. <i>Journal of Neurochemistry</i>. 2003;85(5):1148-1158. doi:<a href=\"https://doi.org/10.1046/j.1471-4159.2003.01751.x\">10.1046/j.1471-4159.2003.01751.x</a>","short":"H. Higashida, J. Zhang, S. Mochida, X. Chen, Y. Shin, M. Noda, K. Hossain, N. Hoshi, M. Hashii, R. Shigemoto, S. Nakanishi, Y. Fukuda, S. Yokoyama, Journal of Neurochemistry 85 (2003) 1148–1158.","ista":"Higashida H, Zhang J, Mochida S, Chen X, Shin Y, Noda M, Hossain K, Hoshi N, Hashii M, Shigemoto R, Nakanishi S, Fukuda Y, Yokoyama S. 2003. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. Journal of Neurochemistry. 85(5), 1148–1158.","chicago":"Higashida, Haruhiro, Jia Zhang, Sumiko Mochida, Xiao Chen, Yeonsook Shin, Mami Noda, Kazi Hossain, et al. “Subtype-Specific Coupling with ADP-Ribosyl Cyclase of Metabotropic Glutamate Receptors in Retina, Cervical Superior Ganglion and NG108-15 Cells.” <i>Journal of Neurochemistry</i>. Wiley-Blackwell, 2003. <a href=\"https://doi.org/10.1046/j.1471-4159.2003.01751.x\">https://doi.org/10.1046/j.1471-4159.2003.01751.x</a>.","apa":"Higashida, H., Zhang, J., Mochida, S., Chen, X., Shin, Y., Noda, M., … Yokoyama, S. (2003). Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. <i>Journal of Neurochemistry</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.1471-4159.2003.01751.x\">https://doi.org/10.1046/j.1471-4159.2003.01751.x</a>","ieee":"H. Higashida <i>et al.</i>, “Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells,” <i>Journal of Neurochemistry</i>, vol. 85, no. 5. Wiley-Blackwell, pp. 1148–1158, 2003."},"day":"01","type":"journal_article","_id":"2631","publication":"Journal of Neurochemistry","extern":1,"volume":85,"status":"public","year":"2003","title":"Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells","doi":"10.1046/j.1471-4159.2003.01751.x","date_created":"2018-12-11T11:58:46Z","page":"1148 - 1158","date_published":"2003-06-01T00:00:00Z","abstract":[{"lang":"eng","text":"Cyclic ADP-ribose (cADP-ribose) is a putative second messenger or modulator. However, the role of cADP-ribose in the downstream signals of the metabotropic glutamate receptors (mGluRs) is unclear. Here, we show that glutamate stimulates ADP-ribosyl cyclase activity in rat or mouse crude membranes of retina via group III mGluRs or in superior cervical ganglion via group I mGluRs. The retina of mGluR6-deficient mice showed no increase in the ADP-ribosyl cyclase level in response to glutamate. GTP enhanced the initial rate of basal and glutamate-stimulated cyclase activity. GTP-γ-S also stimulated basal activity. To determine whether the coupling mode of mGluRs to ADP-ribosyl cyclase is a feature common to individual cloned mGluRs, we expressed each mGluR subtype in NG108-15 neuroblastoma x glioma hybrid cells. The glutamate-induced stimulation of the cyclase occurs preferentially in NG108-15 cells over-expressing mGluRs1, 3, 5, and 6. Cells expressing mGluR2 or mGluRs4 and 7 exhibit inhibition or no coupling, respectively. Glutamate-induced activation or inhibition of the cyclase activity was eliminated after pre-treatment with cholera or pertussis toxin, respectively. Thus, the subtype-specific coupling of mGluRs to ADP-ribosyl cyclase via G proteins suggests that some glutamate-evoked neuronal functions are mediated by cADP-ribose."}],"date_updated":"2021-01-12T06:58:42Z","publisher":"Wiley-Blackwell","publist_id":"4268","issue":"5","month":"06","author":[{"last_name":"Higashida","first_name":"Haruhiro","full_name":"Higashida, Haruhiro"},{"full_name":"Zhang, Jia-Sheng","first_name":"Jia","last_name":"Zhang"},{"last_name":"Mochida","first_name":"Sumiko","full_name":"Mochida, Sumiko"},{"full_name":"Chen, Xiao-Liang","first_name":"Xiao","last_name":"Chen"},{"first_name":"Yeonsook","full_name":"Shin, Yeonsook","last_name":"Shin"},{"first_name":"Mami","full_name":"Noda, Mami","last_name":"Noda"},{"full_name":"Hossain, Kazi Z","first_name":"Kazi","last_name":"Hossain"},{"last_name":"Hoshi","first_name":"Naoto","full_name":"Hoshi, Naoto"},{"full_name":"Hashii, Minako","first_name":"Minako","last_name":"Hashii"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Ryuichi Shigemoto"},{"last_name":"Nakanishi","full_name":"Nakanishi, Shigetada","first_name":"Shigetada"},{"last_name":"Fukuda","full_name":"Fukuda, Yutaka","first_name":"Yutaka"},{"full_name":"Yokoyama, Shigeru","first_name":"Shigeru","last_name":"Yokoyama"}],"publication_status":"published","intvolume":"        85","quality_controlled":0}