Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones

A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, Z. Nusser, Journal of Physiology 542 (2002) 193–210.


Journal Article | Published
Author
Losonczy, Attila; Zhang, Limei; Shigemoto, RyuichiIST Austria ; Somogyi, Péter; Nusser, Zoltán
Abstract
Synapses exhibit different short-term plasticity patterns and this behaviour influences information processing in neuronal networks. We tested how the short-term plasticity of excitatory postsynaptic currents (EPSCs) depends on the postsynaptic cell type, identified by axonal arborizations and molecular markers in the hippocampal CA1 area. Three distinct types of short-term synaptic behaviour (facilitating, depressing and combined facilitating-depressing) were defined by fitting a dynamic neurotransmission model to the data. Approximately 75 % of the oriens-lacunosum-moleculare (O-LM) interneurones received facilitating EPSCs, but in three of 12 O-LM cells EPSCs also showed significant depression. Over 90 % of the O-LM cells were immunopositive for somatostatin and mGluR1α and all tested cells were decorated by strongly mGluR7a positive axon terminals. Responses in eight of 12 basket cells were described well with a model involving only depression, but the other cells displayed combined facilitating-depressing EPSCs. No apparent difference was found between the plasticity of EPSCs in cholecystokinin- or parvalbumin-containing basket cells. In oriens-bistratified cells (O-Bi), two of nine cells showed facilitating EPSCs, another two depressing, and the remaining five cells combined facilitating-depressing EPSCs. Seven of 10 cells tested for somatostatin were immunopositive, but mGluR1α was detectable only in two of 11 tested cells. Furthermore, most O-Bi cells projected to the CA3 area and the subiculum, as well as outside the hippocampal formation. Postsynaptic responses to action potentials recorded in vivo from a CA1 place cell were modelled, and revealed great differences between and within cell types. Our results demonstrate that the short-term plasticity of EPSCs is cell type dependent, but with significant heterogeneity within all three interneurone populations.
Publishing Year
Date Published
2002-07-01
Journal Title
Journal of Physiology
Volume
542
Issue
1
Page
193 - 210
IST-REx-ID

Cite this

Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. Journal of Physiology. 2002;542(1):193-210. doi:10.1113/jphysiol.2002.020024
Losonczy, A., Zhang, L., Shigemoto, R., Somogyi, P., & Nusser, Z. (2002). Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. Journal of Physiology, 542(1), 193–210. https://doi.org/10.1113/jphysiol.2002.020024
Losonczy, Attila, Limei Zhang, Ryuichi Shigemoto, Péter Somogyi, and Zoltán Nusser. “Cell Type Dependence and Variability in the Short-Term Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” Journal of Physiology 542, no. 1 (2002): 193–210. https://doi.org/10.1113/jphysiol.2002.020024.
A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, and Z. Nusser, “Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones,” Journal of Physiology, vol. 542, no. 1, pp. 193–210, 2002.
Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. 2002. Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. Journal of Physiology. 542(1), 193–210.
Losonczy, Attila, et al. “Cell Type Dependence and Variability in the Short-Term Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” Journal of Physiology, vol. 542, no. 1, Wiley-Blackwell, 2002, pp. 193–210, doi:10.1113/jphysiol.2002.020024.
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