{"language":[{"iso":"eng"}],"date_published":"2001-03-01T00:00:00Z","date_created":"2018-12-11T11:58:38Z","issue":"6","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["11285012"]},"publication_status":"published","title":"Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors","intvolume":"        13","publisher":"Wiley-Blackwell","quality_controlled":"1","abstract":[{"lang":"eng","text":"Glutamate receptors have been linked to the regulation of several developmental events in the CNS. By using cortical slices of early postnatal mice, we show that in layer I cells, glutamate produces intracellular calcium ([Ca2+]i) elevations mediated by ionotropic and metabotropic glutamate receptors (mGluRs). The contribution of mGluRs to these responses was demonstrated by application of tACPD, an agonist to groups I and II mGluRs, which evoked [Ca2+]i increases that could be reversibly blocked by MCPG, an antagonist to groups I and II mGluRs. In the absence of extracellular Ca2+, repetitive applications of tACPD or quisqualate, an agonist to group I mGluRs, elicited decreasing [Ca2+]i responses that were restored by refilling a thapsigargin-sensitive Ca2+ store. The use of specific group I mGluR agonists CHPG and DHPG indicated that the functional mGluR in layer I was of the mGluR1 subtype. Subtype specific antibodies confirmed the presence of mGlur1α, but not mGluR5, in Cajal-Retzius (Reelin-immunoreactive) neurons."}],"extern":"1","date_updated":"2023-05-24T12:53:46Z","pmid":1,"month":"03","publication_identifier":{"issn":["0953-816X"]},"article_type":"original","year":"2001","acknowledgement":"MV  and  AF  are  senior  coauthors  of  this  work,  which  was  supported  by Ministerio de Educacion y Cultura, grants SAF97/0195 and SAF 2000-0152-C02-02 to M.V; PB94-0219-CO2-01 and PB97-0582-CO2-01 to A.F., Accio Especial  de  R+D  AE98-18  from  Generalitat  Valenciana,  and  a  Fellowship from Bancaixa-C.S.I.C. to J.R.M.-G. We wish to thank Andre M. Goffinet for his  G10  antireelin  antibody  and  Roberto  Gallego,  Juan  M.  Luque  and  Felix Viana for their constructive criticisms on previous versions of the manuscript.","oa_version":"None","author":[{"first_name":"Galán","full_name":"Martínez, Galán","last_name":"Martínez"},{"last_name":"López Bendito","first_name":"Guillermina","full_name":"López Bendito, Guillermina"},{"last_name":"Luján","full_name":"Luján, Rafael","first_name":"Rafael"},{"first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Fairén","first_name":"Alfonso","full_name":"Fairén, Alfonso"},{"first_name":"Miguel","full_name":"Valdeolmillos, Miguel","last_name":"Valdeolmillos"}],"day":"01","article_processing_charge":"No","doi":"10.1046/j.0953-816X.2001.01494.x","_id":"2606","type":"journal_article","publist_id":"4293","status":"public","publication":"European Journal of Neuroscience","volume":13,"scopus_import":"1","citation":{"chicago":"Martínez, Galán, Guillermina López Bendito, Rafael Luján, Ryuichi Shigemoto, Alfonso Fairén, and Miguel Valdeolmillos. “Cajal-Retzius Cells in Early Postnatal Mouse Cortex Selectively Express Functional Metabotropic Glutamate Receptors.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2001. <a href=\"https://doi.org/10.1046/j.0953-816X.2001.01494.x\">https://doi.org/10.1046/j.0953-816X.2001.01494.x</a>.","short":"G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, M. Valdeolmillos, European Journal of Neuroscience 13 (2001) 1147–1154.","apa":"Martínez, G., López Bendito, G., Luján, R., Shigemoto, R., Fairén, A., &#38; Valdeolmillos, M. (2001). Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1046/j.0953-816X.2001.01494.x\">https://doi.org/10.1046/j.0953-816X.2001.01494.x</a>","ista":"Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos M. 2001. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. European Journal of Neuroscience. 13(6), 1147–1154.","ama":"Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos M. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. <i>European Journal of Neuroscience</i>. 2001;13(6):1147-1154. doi:<a href=\"https://doi.org/10.1046/j.0953-816X.2001.01494.x\">10.1046/j.0953-816X.2001.01494.x</a>","ieee":"G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, and M. Valdeolmillos, “Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors,” <i>European Journal of Neuroscience</i>, vol. 13, no. 6. Wiley-Blackwell, pp. 1147–1154, 2001.","mla":"Martínez, Galán, et al. “Cajal-Retzius Cells in Early Postnatal Mouse Cortex Selectively Express Functional Metabotropic Glutamate Receptors.” <i>European Journal of Neuroscience</i>, vol. 13, no. 6, Wiley-Blackwell, 2001, pp. 1147–54, doi:<a href=\"https://doi.org/10.1046/j.0953-816X.2001.01494.x\">10.1046/j.0953-816X.2001.01494.x</a>."},"page":"1147 - 1154"}