@article{2601, abstract = {Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.}, author = {Ichise, Taeko and Kano, Masanobu and Hashimoto, Kouichi and Yanagihara, Dai and Nakao, Kazuki and Shigemoto, Ryuichi and Katsuki, Motoya and Aiba, Atsu}, issn = {0036-8075}, journal = {Science}, number = {5472}, pages = {1832 -- 1835}, publisher = {American Association for the Advancement of Science}, title = {{mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination}}, doi = {10.1126/science.288.5472.1832}, volume = {288}, year = {2000}, }