mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination

T. Ichise, M. Kano, K. Hashimoto, D. Yanagihara, K. Nakao, R. Shigemoto, M. Katsuki, A. Aiba, Science 288 (2000) 1832–1835.

Download
No fulltext has been uploaded. References only!

Journal Article | Published
Author
; ; ; ; ; ; ;
Abstract
Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.
Publishing Year
Date Published
2000-06-09
Journal Title
Science
Volume
288
Issue
5472
Page
1832 - 1835
IST-REx-ID

Cite this

Ichise T, Kano M, Hashimoto K, et al. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 2000;288(5472):1832-1835. doi:10.1126/science.288.5472.1832
Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., … Aiba, A. (2000). mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science, 288(5472), 1832–1835. https://doi.org/10.1126/science.288.5472.1832
Ichise, Taeko, Masanobu Kano, Kouichi Hashimoto, Dai Yanagihara, Kazuki Nakao, Ryuichi Shigemoto, Motoya Katsuki, and Atsu Aiba. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” Science 288, no. 5472 (2000): 1832–35. https://doi.org/10.1126/science.288.5472.1832.
T. Ichise et al., “mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination,” Science, vol. 288, no. 5472, pp. 1832–1835, 2000.
Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki M, Aiba A. 2000. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 288(5472), 1832–1835.
Ichise, Taeko, et al. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” Science, vol. 288, no. 5472, American Association for the Advancement of Science, 2000, pp. 1832–35, doi:10.1126/science.288.5472.1832.

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar