{"quality_controlled":0,"volume":19,"issue":"9","date_published":"1999-05-01T00:00:00Z","day":"01","intvolume":"        19","status":"public","publisher":"Society for Neuroscience","author":[{"last_name":"Yu","full_name":"Yu, Xiao-Hong","first_name":"Xiao"},{"first_name":"En","full_name":"Zhang, En T","last_name":"Zhang"},{"first_name":"Arthur","last_name":"Craig","full_name":"Craig, Arthur D"},{"full_name":"Ryuichi Shigemoto","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"full_name":"Ribeiro-da-Silva, Alfredo","last_name":"Ribeiro Da Silva","first_name":"Alfredo"},{"first_name":"Yves","full_name":"De Koninck, Yves","last_name":"De Koninck"}],"publist_id":"4305","month":"05","extern":1,"page":"3545 - 3555","publication":"Journal of Neuroscience","title":"NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord","citation":{"ista":"Yu X, Zhang E, Craig A, Shigemoto R, Ribeiro Da Silva A, De Koninck Y. 1999. NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord. Journal of Neuroscience. 19(9), 3545–3555.","apa":"Yu, X., Zhang, E., Craig, A., Shigemoto, R., Ribeiro Da Silva, A., &#38; De Koninck, Y. (1999). NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord. <i>Journal of Neuroscience</i>. Society for Neuroscience.","mla":"Yu, Xiao, et al. “NK-1 Receptor Immunoreactivity in Distinct Morphological Types of Lamina I Neurons of the Primate Spinal Cord.” <i>Journal of Neuroscience</i>, vol. 19, no. 9, Society for Neuroscience, 1999, pp. 3545–55.","short":"X. Yu, E. Zhang, A. Craig, R. Shigemoto, A. Ribeiro Da Silva, Y. De Koninck, Journal of Neuroscience 19 (1999) 3545–3555.","ama":"Yu X, Zhang E, Craig A, Shigemoto R, Ribeiro Da Silva A, De Koninck Y. NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord. <i>Journal of Neuroscience</i>. 1999;19(9):3545-3555.","ieee":"X. Yu, E. Zhang, A. Craig, R. Shigemoto, A. Ribeiro Da Silva, and Y. De Koninck, “NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord,” <i>Journal of Neuroscience</i>, vol. 19, no. 9. Society for Neuroscience, pp. 3545–3555, 1999.","chicago":"Yu, Xiao, En Zhang, Arthur Craig, Ryuichi Shigemoto, Alfredo Ribeiro Da Silva, and Yves De Koninck. “NK-1 Receptor Immunoreactivity in Distinct Morphological Types of Lamina I Neurons of the Primate Spinal Cord.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 1999."},"date_created":"2018-12-11T11:58:34Z","date_updated":"2021-01-12T06:58:27Z","publication_status":"published","year":"1999","_id":"2593","type":"journal_article","abstract":[{"lang":"eng","text":"In cat and monkey, lamina I cells can be classified into three basic morphological types (fusiform, pyramidal, and multipolar), and recent intracellular labeling evidence in the cat indicates that fusiform and multipolar lamina I cells are two different types of nociceptive cells, whereas pyramidal cells are innocuous thermoreceptive-specific. Because earlier observations indicated that only nociceptive dorsal horn neurons respond to substance P (SP), we examined which morphological types of lamina I neurons express receptors for SP (NK-1r). We categorized NK-1r- immunoreactive (IR) lamina I neurons in serial horizontal sections from the cervical and lumbar enlargements of four monkeys. Consistent results were obtained by two independent teams of observers. Nearly all NK-1r-IR cells were fusiform (42%) or multipolar (43%), but only 6% were pyramidal (with 9% unclassified). We obtained similar findings in three monkeys in which we used double-labeling immunocytochemistry to identify NK-1r-IR and spinothalamic lamina I neurons retrogradely labeled with cholera toxin subunit b from the thalamus; most NK-1r-IR lamina I spinothalamic neurons were fusiform (48%) or multipolar (33%), and only 10% were pyramidal. In contrast, most (~75%) pyramidal and some (~25%) fusiform and multipolar lamina I spinothalamic neurons did not display NK-1r immunoreactivity. These data indicate that most fusiform and multipolar lamina I neurons in the monkey can express NK-1r, consistent with the idea that both types are nociceptive, whereas only a small proportion of lamina I pyramidal cells express this receptor, consistent with the previous finding that they are nonnociceptive. However, these findings also indicate that not all nociceptive lamina I neurons express receptors for SP."}]}