{"intvolume":"        19","extern":"1","publication_status":"published","pmid":1,"oa":1,"oa_version":"None","acknowledgement":"This study was supported by National Institute of Health Grants NS 34022 to Y.D.K. and NS 25616 to A.D.C., by Canadian Medical Research Council (MRC) Grants MT 12942 to Y.D.K. and MT 12170 to A.R.S., and by the Barrow Neurological Foundation. Y.D.K. is a Scholar of the Canadian MRC. We thank A. Constantin and A. Forster for expert technical assistance and Dr. M. Wikstrom for generously supplying monoclonal antibodies against CTb.","article_type":"original","author":[{"first_name":"Xiao","last_name":"Yu","full_name":"Yu, Xiao"},{"first_name":"En","full_name":"Zhang, En","last_name":"Zhang"},{"last_name":"Craig","full_name":"Craig, Arthur","first_name":"Arthur"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Ribeiro Da Silva, Alfredo","last_name":"Ribeiro Da Silva","first_name":"Alfredo"},{"last_name":"De Koninck","full_name":"De Koninck, Yves","first_name":"Yves"}],"type":"journal_article","year":"1999","volume":19,"date_updated":"2023-03-27T09:54:40Z","page":"3545 - 3555","month":"05","date_created":"2018-12-11T11:58:34Z","title":"NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord","_id":"2593","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"9","language":[{"iso":"eng"}],"article_processing_charge":"No","publisher":"Society for Neuroscience","abstract":[{"text":"In cat and monkey, lamina I cells can be classified into three basic morphological types (fusiform, pyramidal, and multipolar), and recent intracellular labeling evidence in the cat indicates that fusiform and multipolar lamina I cells are two different types of nociceptive cells, whereas pyramidal cells are innocuous thermoreceptive-specific. Because earlier observations indicated that only nociceptive dorsal horn neurons respond to substance P (SP), we examined which morphological types of lamina I neurons express receptors for SP (NK-1r). We categorized NK-1r- immunoreactive (IR) lamina I neurons in serial horizontal sections from the cervical and lumbar enlargements of four monkeys. Consistent results were obtained by two independent teams of observers. Nearly all NK-1r-IR cells were fusiform (42%) or multipolar (43%), but only 6% were pyramidal (with 9% unclassified). We obtained similar findings in three monkeys in which we used double-labeling immunocytochemistry to identify NK-1r-IR and spinothalamic lamina I neurons retrogradely labeled with cholera toxin subunit b from the thalamus; most NK-1r-IR lamina I spinothalamic neurons were fusiform (48%) or multipolar (33%), and only 10% were pyramidal. In contrast, most (~75%) pyramidal and some (~25%) fusiform and multipolar lamina I spinothalamic neurons did not display NK-1r immunoreactivity. These data indicate that most fusiform and multipolar lamina I neurons in the monkey can express NK-1r, consistent with the idea that both types are nociceptive, whereas only a small proportion of lamina I pyramidal cells express this receptor, consistent with the previous finding that they are nonnociceptive. However, these findings also indicate that not all nociceptive lamina I neurons express receptors for SP.","lang":"eng"}],"publist_id":"4305","citation":{"ieee":"X. Yu, E. Zhang, A. Craig, R. Shigemoto, A. Ribeiro Da Silva, and Y. De Koninck, “NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord,” <i>Journal of Neuroscience</i>, vol. 19, no. 9. Society for Neuroscience, pp. 3545–3555, 1999.","ama":"Yu X, Zhang E, Craig A, Shigemoto R, Ribeiro Da Silva A, De Koninck Y. NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord. <i>Journal of Neuroscience</i>. 1999;19(9):3545-3555. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999\">10.1523/JNEUROSCI.19-09-03545.1999</a>","chicago":"Yu, Xiao, En Zhang, Arthur Craig, Ryuichi Shigemoto, Alfredo Ribeiro Da Silva, and Yves De Koninck. “NK-1 Receptor Immunoreactivity in Distinct Morphological Types of Lamina I Neurons of the Primate Spinal Cord.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 1999. <a href=\"https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999\">https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999</a>.","short":"X. Yu, E. Zhang, A. Craig, R. Shigemoto, A. Ribeiro Da Silva, Y. De Koninck, Journal of Neuroscience 19 (1999) 3545–3555.","apa":"Yu, X., Zhang, E., Craig, A., Shigemoto, R., Ribeiro Da Silva, A., &#38; De Koninck, Y. (1999). NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999\">https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999</a>","mla":"Yu, Xiao, et al. “NK-1 Receptor Immunoreactivity in Distinct Morphological Types of Lamina I Neurons of the Primate Spinal Cord.” <i>Journal of Neuroscience</i>, vol. 19, no. 9, Society for Neuroscience, 1999, pp. 3545–55, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999\">10.1523/JNEUROSCI.19-09-03545.1999</a>.","ista":"Yu X, Zhang E, Craig A, Shigemoto R, Ribeiro Da Silva A, De Koninck Y. 1999. NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord. Journal of Neuroscience. 19(9), 3545–3555."},"scopus_import":"1","doi":"10.1523/JNEUROSCI.19-09-03545.1999","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782224/","open_access":"1"}],"publication_identifier":{"issn":["0270-6474"]},"date_published":"1999-05-01T00:00:00Z","status":"public","day":"01","publication":"Journal of Neuroscience","external_id":{"pmid":["10212314"]},"quality_controlled":"1"}