---
_id: '2591'
abstract:
- lang: eng
text: The occurrence and distribution of the preferred receptor for the neuropeptide,
substance P (SP), the neurokinin-1 receptor (NK1R) was investigated in the vascular
supply of the rat sciatic nerve. Messenger RNA for NK1R was demonstrated by RT-PCR
in the epineurial layer where the majority of small arteries and arterioles feeding
the endoneurial vasculature are located. Immunoreactivity to NK1R-protein was
localized on the smooth muscle cells of these arterial vessels by means of immunofluorescence
using a polyclonal NK1R antiserum. This muscular localization of NK1R explains
the previously reported [Zochodne, D.W. and Ho, L.T., J. Physiol. 444 (1991) 615-
630] moderate vasoconstrictor rather than vasodilator effects of SP in this vascular
bed.
acknowledgement: The skillful technical assistance of Ms. T. Fischbach and Ms. K.
Michael and the secretarial help of Ms. P. Berger are gratefully appreciated.
article_processing_charge: No
article_type: original
author:
- first_name: Wolfgang
full_name: Kummer, Wolfgang
last_name: Kummer
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Rainer
full_name: Haberberger, Rainer
last_name: Haberberger
citation:
ama: Kummer W, Shigemoto R, Haberberger R. Smooth muscle cells are the site of neurokinin-1
receptor localization in the arterial supply of the rat sciatic nerve. Neuroscience
Letters. 1999;259(2):119-122. doi:10.1016/S0304-3940(98)00926-4
apa: Kummer, W., Shigemoto, R., & Haberberger, R. (1999). Smooth muscle cells
are the site of neurokinin-1 receptor localization in the arterial supply of the
rat sciatic nerve. Neuroscience Letters. Elsevier. https://doi.org/10.1016/S0304-3940(98)00926-4
chicago: Kummer, Wolfgang, Ryuichi Shigemoto, and Rainer Haberberger. “Smooth Muscle
Cells Are the Site of Neurokinin-1 Receptor Localization in the Arterial Supply
of the Rat Sciatic Nerve.” Neuroscience Letters. Elsevier, 1999. https://doi.org/10.1016/S0304-3940(98)00926-4.
ieee: W. Kummer, R. Shigemoto, and R. Haberberger, “Smooth muscle cells are the
site of neurokinin-1 receptor localization in the arterial supply of the rat sciatic
nerve,” Neuroscience Letters, vol. 259, no. 2. Elsevier, pp. 119–122, 1999.
ista: Kummer W, Shigemoto R, Haberberger R. 1999. Smooth muscle cells are the site
of neurokinin-1 receptor localization in the arterial supply of the rat sciatic
nerve. Neuroscience Letters. 259(2), 119–122.
mla: Kummer, Wolfgang, et al. “Smooth Muscle Cells Are the Site of Neurokinin-1
Receptor Localization in the Arterial Supply of the Rat Sciatic Nerve.” Neuroscience
Letters, vol. 259, no. 2, Elsevier, 1999, pp. 119–22, doi:10.1016/S0304-3940(98)00926-4.
short: W. Kummer, R. Shigemoto, R. Haberberger, Neuroscience Letters 259 (1999)
119–122.
date_created: 2018-12-11T11:58:33Z
date_published: 1999-01-08T00:00:00Z
date_updated: 2023-03-27T10:11:02Z
day: '08'
doi: 10.1016/S0304-3940(98)00926-4
extern: '1'
external_id:
pmid:
- '10025572'
intvolume: ' 259'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 119 - 122
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4307'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Smooth muscle cells are the site of neurokinin-1 receptor localization in the
arterial supply of the rat sciatic nerve
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 259
year: '1999'
...