@article{2591, abstract = {The occurrence and distribution of the preferred receptor for the neuropeptide, substance P (SP), the neurokinin-1 receptor (NK1R) was investigated in the vascular supply of the rat sciatic nerve. Messenger RNA for NK1R was demonstrated by RT-PCR in the epineurial layer where the majority of small arteries and arterioles feeding the endoneurial vasculature are located. Immunoreactivity to NK1R-protein was localized on the smooth muscle cells of these arterial vessels by means of immunofluorescence using a polyclonal NK1R antiserum. This muscular localization of NK1R explains the previously reported [Zochodne, D.W. and Ho, L.T., J. Physiol. 444 (1991) 615- 630] moderate vasoconstrictor rather than vasodilator effects of SP in this vascular bed.}, author = {Kummer, Wolfgang and Shigemoto, Ryuichi and Haberberger, Rainer}, issn = {0304-3940}, journal = {Neuroscience Letters}, number = {2}, pages = {119 -- 122}, publisher = {Elsevier}, title = {{Smooth muscle cells are the site of neurokinin-1 receptor localization in the arterial supply of the rat sciatic nerve}}, doi = {10.1016/S0304-3940(98)00926-4}, volume = {259}, year = {1999}, }