Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat

H. Li, H. Ohishi, A. Kinoshita, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience Letters 223 (1997) 153–156.

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Abstract
It was examined electron microscopically in the rat if a metabotropic glutamate receptor, mGluR7, might be localized in axon terminals of nociceptive, primary afferent fibers in laminae I and II of the spinal dorsal horn. Nociceptive nature of axon terminals showing mGluR7-like immunoreactivity (mGluR7-LI) was indicated by binding to the isolectin I-B4 from Griffonia simplicifolia (I-B4), or by substance P-like immunoreactivity (SP-LI). Axon terminals labeled with immunogold particles indicating mGluR7-LI were usually filled with round synaptic vesicles and were in asymmetric synaptic contact with dendritic or somatic profiles; occasionally they contained pleomorphic vesicles and were in symmetric synaptic contact with somatic profiles in lamina II. The double-labeling studies revealed that most of axon terminals with I-B4 labeling as well as a small population of axon terminals with SP-LI, showed mGluR7-LI. About one-third or much smaller population of axon terminals with mGluR7-LI in laminae I and II were labeled, respectively, with I-B4 or SP-LI; these were in asymmetric synaptic contact with dendritic profiles.
Publishing Year
Date Published
1997-02-28
Journal Title
Neuroscience Letters
Volume
223
Issue
3
Page
153 - 156
IST-REx-ID

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Li H, Ohishi H, Kinoshita A, Shigemoto R, Nomura S, Mizuno N. Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat. Neuroscience Letters. 1997;223(3):153-156. doi:10.1016/S0304-3940(97)13429-2
Li, H., Ohishi, H., Kinoshita, A., Shigemoto, R., Nomura, S., & Mizuno, N. (1997). Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat. Neuroscience Letters, 223(3), 153–156. https://doi.org/10.1016/S0304-3940(97)13429-2
Li, He, Hitoshi Ohishi, Ayae Kinoshita, Ryuichi Shigemoto, Sakashi Nomura, and Noboru Mizuno. “Localization of a Metabotropic Glutamate Receptor, MGluR7, in Axon Terminals of Presumed Nociceptive, Primary Afferent Fibers in the Superficial Layers of the Spinal Dorsal Horn: An Electron Microscope Study in the Rat.” Neuroscience Letters 223, no. 3 (1997): 153–56. https://doi.org/10.1016/S0304-3940(97)13429-2.
H. Li, H. Ohishi, A. Kinoshita, R. Shigemoto, S. Nomura, and N. Mizuno, “Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat,” Neuroscience Letters, vol. 223, no. 3, pp. 153–156, 1997.
Li H, Ohishi H, Kinoshita A, Shigemoto R, Nomura S, Mizuno N. 1997. Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat. Neuroscience Letters. 223(3), 153–156.
Li, He, et al. “Localization of a Metabotropic Glutamate Receptor, MGluR7, in Axon Terminals of Presumed Nociceptive, Primary Afferent Fibers in the Superficial Layers of the Spinal Dorsal Horn: An Electron Microscope Study in the Rat.” Neuroscience Letters, vol. 223, no. 3, Elsevier, 1997, pp. 153–56, doi:10.1016/S0304-3940(97)13429-2.

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