@article{2573, abstract = {Developmental changes of the distribution pattern of substance P receptor (SPR) were investigated immunohistochemically in the rat striatum. The SPR immunoreactivity in the striatum first emerged at postnatal day 1 and transiently showed a patchy pattern of distribution until it displayed the adult pattern of homogeneous distribution by the end of the third postnatal week. The SPR-immunoreactive patches were most marked in the medial and dorsolateral parts of the striatum, as well as in the subcallosal streak. They matched tyrosine hydroxylase-enriched areas and, conversely, avoided calbindin-enriched zones. No neurons within the SPR-immunoreactive patches contained either choline acetyltransferase or somatostatin, which is known to be contained in intrinsic neurons in the striatum. The vast majority of SPR-immunoreactive patch neurons also contained DARPP-32, a phosphoprotein that is expressed in striatal projection neurons with D1 dopamine receptor. The results indicate that SPR-immunoreactive patches which appear transiently in the developing striatum are in register with the striatal patch compartment, and that SPR immunoreactivity within these patches may be expressed on projection neurons rather than intrinsic neurons. Such SPR immunoreactivity in projection neurons in striatal patches may fade out in adulthood.}, author = {Tokuno, Hironobu and Takada, Masahiko and Kaneko, Takeshi and Shigemoto, Ryuichi and Mizuno, Noboru}, issn = {0165-3806}, journal = {Developmental Brain Research}, number = {1}, pages = {107 -- 117}, publisher = {Elsevier}, title = {{Patchy distribution of substance P receptor immunoreactivity in the developing rat striatum}}, doi = {10.1016/0165-3806(96)00080-6}, volume = {95}, year = {1996}, }