Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2

M. Yokoi, K. Kobayashi, T. Manabe, T. Takahashi, I. Sakaguchi, G. Katsuura, R. Shigemoto, H. Ohishi, S. Nomura, K. Nakamura, K. Nakao, M. Katsuki, S. Nakanishi, Science 273 (1996) 645–647.

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Author
Yokoi, Mineto; Kobayashi, Kazuto; Manabe, Toshiya; Takahashi, Tomoyuki; Sakaguchi, Isako; Katsuura, Goro; Shigemoto, RyuichiIST Austria ; Ohishi, Hitoshi; Nomura, Sakashi; Nakamura, Kenji; Nakao, Kazuki; Katsuki, Motoya
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Abstract
Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.
Publishing Year
Date Published
1996-08-02
Journal Title
Science
Volume
273
Issue
5275
Page
645 - 647
IST-REx-ID

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Yokoi M, Kobayashi K, Manabe T, et al. Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 1996;273(5275):645-647. doi:10.1126/science.273.5275.645
Yokoi, M., Kobayashi, K., Manabe, T., Takahashi, T., Sakaguchi, I., Katsuura, G., … Nakanishi, S. (1996). Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.273.5275.645
Yokoi, Mineto, Kazuto Kobayashi, Toshiya Manabe, Tomoyuki Takahashi, Isako Sakaguchi, Goro Katsuura, Ryuichi Shigemoto, et al. “Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking MGluR2.” Science. American Association for the Advancement of Science, 1996. https://doi.org/10.1126/science.273.5275.645.
M. Yokoi et al., “Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2,” Science, vol. 273, no. 5275. American Association for the Advancement of Science, pp. 645–647, 1996.
Yokoi M, Kobayashi K, Manabe T, Takahashi T, Sakaguchi I, Katsuura G, Shigemoto R, Ohishi H, Nomura S, Nakamura K, Nakao K, Katsuki M, Nakanishi S. 1996. Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 273(5275), 645–647.
Yokoi, Mineto, et al. “Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking MGluR2.” Science, vol. 273, no. 5275, American Association for the Advancement of Science, 1996, pp. 645–47, doi:10.1126/science.273.5275.645.

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