TY - JOUR AB - The present study indicated presynaptic localization of a metabotropic glutamate receptor, mGluR8, in projection neurons of the main olfactory bulb of rat. An antibody was produced by using a peptide corresponding to C-terminal 23 amino acids of mouse mGluR8. It was confirmed that the C-terminal 23 amino acids of rat mGluR8 were the same as those of mouse mGluR8 except for one, and that the antibody specifically recognized mGluR8 in the rat rhinencephalon. In layer Ia of the piriform cortex (a target area of projection fibers from the main olfactory bulb), mGluR8-like immunoreactivity (mGluR8-LI) was reduced after transection of the lateral olfactory tract, and mGluR8-LI was observed in axon terminals which were filled with round synaptic vesicles and made asymmetric synapses with dendritic spines. AU - Kinoshita, Ayae AU - Ohishi, Hitoshi AU - Neki, Akio AU - Nomura, Sakashi AU - Shigemoto, Ryuichi AU - Takada, Masahiko AU - Nakanishi, Shigetada AU - Mizuno, Noboru ID - 2566 IS - 1 JF - Neuroscience Letters SN - 0304-3940 TI - Presynaptic localization of a metabotropic glutamate receptor, mGluR8, in the rhinencephalic areas: A light and electron microscope study in the rat VL - 207 ER -