Localization of substance P receptors in central neural structures controlling daily rhythms in nocturnal rodents

G. Mick, R. Shigemoto, K. Kitahama, Comptes Rendus de l’Academie Des Sciences - Series III 318 (1995) 209–217.

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Journal Article | Published
Author
Mick, Gérard; Shigemoto, RyuichiIST Austria ; Kitahama, Kunio
Abstract
Brain areas involved in the genesis and control of daily rhythms receive a prominent neural input that contains the neurotransmitter substance P (SP), a peptide putatively involved in the synchronization of circadian rhythms by environmental light. We investigated the localization of receptors to SP in the suprachiasmatic nucleus of the hypothalamus (SCN) and in the intergeniculate leaflet of the thalamus (IGL) of the rat and hamster using in situ hybridization histochemistry and immunohistochemistry. Consistently with that previously described in the rat, a neuronal population distributed along the lateral margin and at the dorso-latero-caudal aspect of the hamster SCN expresses moderately the mRNA encoding the SP receptor. In both rat and hamster, immunohistochemical data confirm the previous finding and reveal an almost complete absence of SP receptors in the ventral part of the SCN which receives a direct projection from the retina. In the IGL of both species, numerous neurons prominently express the mRNA encoding the SP receptor. The immunostaining shows a high density of SP receptors on perikarya and dendrites throughout the nucleus. A dense staining is also observed on individual cells and processes bordering the lumen of blood vessels in the SCN and IGL. These observations in nocturnal rodents reveal the following featured (1) a novel neuronal subpopulation located at the intero-dorsal edge of the SCN that likely, receives a non-retinal SP-containing input; (2) a large number of neurons in the IGL that might receive a SP-containing input arising from the raphe; (3) the absence of SP receptors in the retinorecipient part of the SCN, raising the question of the biological significance of SP-containing fibers distributing within the ventral part of this nucleus; (4) the presence of perivascular cells bearing a high density of SP receptors, which might contribute to the cyclic regulation of local blood flow.
Publishing Year
Date Published
1995-02-01
Journal Title
Comptes Rendus de l'Academie des Sciences - Series III
Volume
318
Issue
2
Page
209 - 217
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Mick G, Shigemoto R, Kitahama K. Localization of substance P receptors in central neural structures controlling daily rhythms in nocturnal rodents. Comptes Rendus de l’Academie des Sciences - Series III. 1995;318(2):209-217.
Mick, G., Shigemoto, R., & Kitahama, K. (1995). Localization of substance P receptors in central neural structures controlling daily rhythms in nocturnal rodents. Comptes Rendus de l’Academie Des Sciences - Series III, 318(2), 209–217.
Mick, Gérard, Ryuichi Shigemoto, and Kunio Kitahama. “Localization of Substance P Receptors in Central Neural Structures Controlling Daily Rhythms in Nocturnal Rodents.” Comptes Rendus de l’Academie Des Sciences - Series III 318, no. 2 (1995): 209–17.
G. Mick, R. Shigemoto, and K. Kitahama, “Localization of substance P receptors in central neural structures controlling daily rhythms in nocturnal rodents,” Comptes Rendus de l’Academie des Sciences - Series III, vol. 318, no. 2, pp. 209–217, 1995.
Mick G, Shigemoto R, Kitahama K. 1995. Localization of substance P receptors in central neural structures controlling daily rhythms in nocturnal rodents. Comptes Rendus de l’Academie des Sciences - Series III. 318(2), 209–217.
Mick, Gérard, et al. “Localization of Substance P Receptors in Central Neural Structures Controlling Daily Rhythms in Nocturnal Rodents.” Comptes Rendus de l’Academie Des Sciences - Series III, vol. 318, no. 2, Gauthier Villars Editeur, 1995, pp. 209–17.

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