Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex
Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. 1994. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. 13(1), 55–66.
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Journal Article
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Author
Ohishi, Hitoshi;
Ogawa Meguro, Reiko;
Shigemoto, RyuichiISTA 
;
Kaneko, Takeshi;
Nakanishi, Shigetada;
Mizuno, Noboru
;
Kaneko, Takeshi;
Nakanishi, Shigetada;
Mizuno, NoboruAbstract
The distribution of the metabotropic glutamate receptors mGluR2 and mGluR3 was immunohistochemically examined in the rat cerebellar cortex at both light and electron microscope levels. An antibody was raised against a fusion protein containing a C-terminal portion of mGluR2. On immunoblot, the antibody reacted with both mGluR2 and mGluR3 in rat brain. mGluR2/3 immunoreactivity was expressed in cell bodies, dendrites, and axon terminals of Golgi cells, as well as in presumed glial processes. Golgi axon terminals with mGluR2/3 immunoreactivity were often encountered in the vicinity of glutamatergic mossy fiber terminals. The results suggest that transmitter glutamate may exert control influences upon Golgi cells not only through dendritic mGluR2/3, but also through axonal mGluR2/3.
Publishing Year
Date Published
1994-07-01
Journal Title
Neuron
Acknowledgement
We are grateful to Mr. Akira Uesugi for photographic help. This work has been supported in part by research grants from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part
by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact.
Volume
13
Issue
1
Page
55 - 66
ISSN
IST-REx-ID
Cite this
Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. 1994;13(1):55-66. doi:10.1016/0896-6273(94)90459-6
Ohishi, H., Ogawa Meguro, R., Shigemoto, R., Kaneko, T., Nakanishi, S., & Mizuno, N. (1994). Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(94)90459-6
Ohishi, Hitoshi, Reiko Ogawa Meguro, Ryuichi Shigemoto, Takeshi Kaneko, Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of Metabotropic Glutamate Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” Neuron. Elsevier, 1994. https://doi.org/10.1016/0896-6273(94)90459-6.
H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, and N. Mizuno, “Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex,” Neuron, vol. 13, no. 1. Elsevier, pp. 55–66, 1994.
Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. 1994. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. 13(1), 55–66.
Ohishi, Hitoshi, et al. “Immunohistochemical Localization of Metabotropic Glutamate Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” Neuron, vol. 13, no. 1, Elsevier, 1994, pp. 55–66, doi:10.1016/0896-6273(94)90459-6.
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