{"abstract":[{"lang":"eng","text":"Distribution of the mRNAs for three subtypes of prostaglandin E (PGE) receptors in the mouse kidney was investigated by in situ hybridization. The mRNA for EP1 subtype, which is coupled to Ca2+ mobilization, was specifically localized to the collecting ducts from the cortex to the papilla. The mRNA for EP2 subtype, which is linked to stimulation of adenylate cyclase, was localized to the glomeruli. The mRNA for EP3 subtype, which is coupled to inhibition of adenylate cyclase, was located densely in the tubules in the outer medulla and in the distal tubules in the cortex. These results exhibit distinct cellular localization of three subtypes of PGE receptor in the kidney and suggest that PGE2 exerts multiple functions via these subtypes expressed in different segments of the nephron."}],"publication_status":"published","title":"Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney","article_type":"original","publisher":"American Physiological Society","language":[{"iso":"eng"}],"status":"public","issue":"5","date_published":"1994-05-01T00:00:00Z","publist_id":"4345","year":"1994","citation":{"chicago":"Sugimoto, Yukihiko, Tsunehisa Namba, Ryuichi Shigemoto, Manabu Negishi, Atsushi Ichikawa, and Shuh Narumiya. “Distinct Cellular Localization of MRNAs for Three Subtypes of Prostaglandin E Receptor in Kidney.” <i>American Journal of Physiology</i>. American Physiological Society, 1994. <a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">https://doi.org/10.1152/ajprenal.1994.266.5.F823</a>.","ista":"Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. 1994. Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. American Journal of Physiology. 266(5), F823–F828.","short":"Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, S. Narumiya, American Journal of Physiology 266 (1994) F823–F828.","ama":"Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. <i>American Journal of Physiology</i>. 1994;266(5):F823-F828. doi:<a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">10.1152/ajprenal.1994.266.5.F823</a>","mla":"Sugimoto, Yukihiko, et al. “Distinct Cellular Localization of MRNAs for Three Subtypes of Prostaglandin E Receptor in Kidney.” <i>American Journal of Physiology</i>, vol. 266, no. 5, American Physiological Society, 1994, pp. F823–28, doi:<a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">10.1152/ajprenal.1994.266.5.F823</a>.","ieee":"Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, and S. Narumiya, “Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney,” <i>American Journal of Physiology</i>, vol. 266, no. 5. American Physiological Society, pp. F823–F828, 1994.","apa":"Sugimoto, Y., Namba, T., Shigemoto, R., Negishi, M., Ichikawa, A., &#38; Narumiya, S. (1994). Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. <i>American Journal of Physiology</i>. American Physiological Society. <a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">https://doi.org/10.1152/ajprenal.1994.266.5.F823</a>"},"date_created":"2018-12-11T11:58:21Z","day":"01","date_updated":"2022-06-07T15:03:51Z","doi":"10.1152/ajprenal.1994.266.5.F823","publication":"American Journal of Physiology","extern":"1","pmid":1,"main_file_link":[{"url":"https://journals.physiology.org/doi/abs/10.1152/ajprenal.1994.266.5.F823"}],"month":"05","page":"F823 - F828","intvolume":"       266","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["8203567"]},"quality_controlled":"1","acknowledgement":"We thank Drs. Noboru Mizuno, Tsuyoshi Watanabe, Akihide Nakao, Chihiro Akazawa, and Akira Uesugi for invaluable discussions and photographic support. This work was supported in part by Scientific Research Grants-inAid 05404020, 04255103, 05771975, 05671816, and 05454568 from the Ministry of Education, Science and Culture of Japan and by grants from the Mitsubishi Foundation and the Takeda Science Foundation.","oa_version":"None","publication_identifier":{"issn":["0363-6127"]},"_id":"2553","volume":266,"author":[{"last_name":"Sugimoto","first_name":"Yukihiko","full_name":"Sugimoto, Yukihiko"},{"last_name":"Namba","first_name":"Tsunehisa","full_name":"Namba, Tsunehisa"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"},{"full_name":"Negishi, Manabu","first_name":"Manabu","last_name":"Negishi"},{"last_name":"Ichikawa","full_name":"Ichikawa, Atsushi","first_name":"Atsushi"},{"last_name":"Narumiya","first_name":"Shuh","full_name":"Narumiya, Shuh"}],"scopus_import":"1","type":"journal_article","article_processing_charge":"No"}