Induction mechanism of long term depression in cultured Purkinje neurons

T. Hirano, K. Kasono, R. Shigemoto, S. Nakanishi, in:, Biomedical Research Foundation, 1994, pp. 79–81.

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Conference Paper | Published
Author
Hirano, Tomoo; Kasono, Keizo; Shigemoto, RyuichiIST Austria ; Nakanishi, Shigetada
Series Title
Biomedical Research
Abstract
The induction mechanism of cerebellar long term depression (LTD) has been analysed in a cerebellar culture. Using nitr-5, a photolabile Ca chelator, we demonstrated that an increase in postsynaptic Ca together with glutamate application is sufficient to induce the LTD of glutamate responsiveness in Purkinje cells. It has also been shown that one subtype of genetically defined metabotropic glutamate receptor, mGluR1, is involved in the LTD induction. We raised antibodies which specifically recognized mGluR1 and inactivated its function. The antibodies suppressed the LTD induction in the cultured Purkinje cells.
Publishing Year
Date Published
1994-01-01
Volume
15
Issue
SUPPL. 1
Page
79 - 81
Conference
Unknown (0388-6107)
IST-REx-ID

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Hirano T, Kasono K, Shigemoto R, Nakanishi S. Induction mechanism of long term depression in cultured Purkinje neurons. In: Vol 15. Biomedical Research Foundation; 1994:79-81.
Hirano, T., Kasono, K., Shigemoto, R., & Nakanishi, S. (1994). Induction mechanism of long term depression in cultured Purkinje neurons (Vol. 15, pp. 79–81). Presented at the Unknown (0388-6107), Biomedical Research Foundation.
Hirano, Tomoo, Keizo Kasono, Ryuichi Shigemoto, and Shigetada Nakanishi. “Induction Mechanism of Long Term Depression in Cultured Purkinje Neurons,” 15:79–81. Biomedical Research Foundation, 1994.
T. Hirano, K. Kasono, R. Shigemoto, and S. Nakanishi, “Induction mechanism of long term depression in cultured Purkinje neurons,” presented at the Unknown (0388-6107), 1994, vol. 15, no. SUPPL. 1, pp. 79–81.
Hirano T, Kasono K, Shigemoto R, Nakanishi S. 1994. Induction mechanism of long term depression in cultured Purkinje neurons. Unknown (0388-6107), Biomedical Research, vol. 15. 79–81.
Hirano, Tomoo, et al. Induction Mechanism of Long Term Depression in Cultured Purkinje Neurons. Vol. 15, no. SUPPL. 1, Biomedical Research Foundation, 1994, pp. 79–81.

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