---
_id: '2544'
abstract:
- lang: eng
text: VARIOUS functions of glutamate transmission are mediated by both ionotropic
and metabotropic glutamate receptors1. The metabotropic glutamate receptors (mGluRs)
consist of at least six different subtypes that are classified into three subgroups,
mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6 (refs 1-5), but their physiological
roles are largely unknown. Here we report the identification of a very potent
agonist for mGluR2/mGluR3, DCG-IV, and the specific localization of mGluR2 in
granule cell dendrites that form dendrodendritic synapses with mitral cells in
the accessory olfactory bulb. Using the DCG-IV agonist for mGluR2 in combination
with slice patchrecording, we demonstrate that the granule cell mGluR2 presynaptically
suppresses inhibitory GABA (γ-aminobutyrate) transmission to the mitral cell.
Our results indicate that mGluR2 in granule cells plays an important role in the
persistent excitation of olfactory sensory transmission in the accessory olfactory
bulb by relieving mitral cells from the GABA inhibition.
acknowledgement: 'We thank Y. Ohfune and K. Shimamoto for DCG-IV, M. Kuno for advice
and A. Uesugi for photographic assistance. Partly supported by research grants from
the Ministry of Education, Science and Culture of Japan, the Ministry of Health
and Welfare of Japan and the Senri Life Science Foundation. '
article_processing_charge: No
article_type: original
author:
- first_name: Yasunori
full_name: Hayashi, Yasunori
last_name: Hayashi
- first_name: Akiko
full_name: Momiyama, Akiko
last_name: Momiyama
- first_name: Tomoyuki
full_name: Takahashi, Tomoyuki
last_name: Takahashi
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Reiko
full_name: Ogawa Meguro, Reiko
last_name: Ogawa Meguro
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Hayashi Y, Momiyama A, Takahashi T, et al. Role of a metabotropic glutamate
receptor in synaptic modulation in the accessory olfactory bulb. Nature.
1993;366(6456):687-690. doi:10.1038/366687a0
apa: Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Ogawa Meguro, R., Shigemoto,
R., … Nakanishi, S. (1993). Role of a metabotropic glutamate receptor in synaptic
modulation in the accessory olfactory bulb. Nature. Nature Publishing Group.
https://doi.org/10.1038/366687a0
chicago: Hayashi, Yasunori, Akiko Momiyama, Tomoyuki Takahashi, Hitoshi Ohishi,
Reiko Ogawa Meguro, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi.
“Role of a Metabotropic Glutamate Receptor in Synaptic Modulation in the Accessory
Olfactory Bulb.” Nature. Nature Publishing Group, 1993. https://doi.org/10.1038/366687a0.
ieee: Y. Hayashi et al., “Role of a metabotropic glutamate receptor in synaptic
modulation in the accessory olfactory bulb,” Nature, vol. 366, no. 6456.
Nature Publishing Group, pp. 687–690, 1993.
ista: Hayashi Y, Momiyama A, Takahashi T, Ohishi H, Ogawa Meguro R, Shigemoto R,
Mizuno N, Nakanishi S. 1993. Role of a metabotropic glutamate receptor in synaptic
modulation in the accessory olfactory bulb. Nature. 366(6456), 687–690.
mla: Hayashi, Yasunori, et al. “Role of a Metabotropic Glutamate Receptor in Synaptic
Modulation in the Accessory Olfactory Bulb.” Nature, vol. 366, no. 6456,
Nature Publishing Group, 1993, pp. 687–90, doi:10.1038/366687a0.
short: Y. Hayashi, A. Momiyama, T. Takahashi, H. Ohishi, R. Ogawa Meguro, R. Shigemoto,
N. Mizuno, S. Nakanishi, Nature 366 (1993) 687–690.
date_created: 2018-12-11T11:58:18Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-31T09:36:00Z
day: '01'
doi: 10.1038/366687a0
extern: '1'
external_id:
pmid:
- '7903116 '
intvolume: ' 366'
issue: '6456'
language:
- iso: eng
main_file_link:
- url: https://www.nature.com/articles/366687a0
month: '01'
oa_version: None
page: 687 - 690
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '4354'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Role of a metabotropic glutamate receptor in synaptic modulation in the accessory
olfactory bulb
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 366
year: '1993'
...