--- _id: '2544' abstract: - lang: eng text: VARIOUS functions of glutamate transmission are mediated by both ionotropic and metabotropic glutamate receptors1. The metabotropic glutamate receptors (mGluRs) consist of at least six different subtypes that are classified into three subgroups, mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6 (refs 1-5), but their physiological roles are largely unknown. Here we report the identification of a very potent agonist for mGluR2/mGluR3, DCG-IV, and the specific localization of mGluR2 in granule cell dendrites that form dendrodendritic synapses with mitral cells in the accessory olfactory bulb. Using the DCG-IV agonist for mGluR2 in combination with slice patchrecording, we demonstrate that the granule cell mGluR2 presynaptically suppresses inhibitory GABA (γ-aminobutyrate) transmission to the mitral cell. Our results indicate that mGluR2 in granule cells plays an important role in the persistent excitation of olfactory sensory transmission in the accessory olfactory bulb by relieving mitral cells from the GABA inhibition. acknowledgement: 'We thank Y. Ohfune and K. Shimamoto for DCG-IV, M. Kuno for advice and A. Uesugi for photographic assistance. Partly supported by research grants from the Ministry of Education, Science and Culture of Japan, the Ministry of Health and Welfare of Japan and the Senri Life Science Foundation. ' article_processing_charge: No article_type: original author: - first_name: Yasunori full_name: Hayashi, Yasunori last_name: Hayashi - first_name: Akiko full_name: Momiyama, Akiko last_name: Momiyama - first_name: Tomoyuki full_name: Takahashi, Tomoyuki last_name: Takahashi - first_name: Hitoshi full_name: Ohishi, Hitoshi last_name: Ohishi - first_name: Reiko full_name: Ogawa Meguro, Reiko last_name: Ogawa Meguro - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Noboru full_name: Mizuno, Noboru last_name: Mizuno - first_name: Shigetada full_name: Nakanishi, Shigetada last_name: Nakanishi citation: ama: Hayashi Y, Momiyama A, Takahashi T, et al. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. 1993;366(6456):687-690. doi:10.1038/366687a0 apa: Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Ogawa Meguro, R., Shigemoto, R., … Nakanishi, S. (1993). Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. Nature Publishing Group. https://doi.org/10.1038/366687a0 chicago: Hayashi, Yasunori, Akiko Momiyama, Tomoyuki Takahashi, Hitoshi Ohishi, Reiko Ogawa Meguro, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Role of a Metabotropic Glutamate Receptor in Synaptic Modulation in the Accessory Olfactory Bulb.” Nature. Nature Publishing Group, 1993. https://doi.org/10.1038/366687a0. ieee: Y. Hayashi et al., “Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb,” Nature, vol. 366, no. 6456. Nature Publishing Group, pp. 687–690, 1993. ista: Hayashi Y, Momiyama A, Takahashi T, Ohishi H, Ogawa Meguro R, Shigemoto R, Mizuno N, Nakanishi S. 1993. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. 366(6456), 687–690. mla: Hayashi, Yasunori, et al. “Role of a Metabotropic Glutamate Receptor in Synaptic Modulation in the Accessory Olfactory Bulb.” Nature, vol. 366, no. 6456, Nature Publishing Group, 1993, pp. 687–90, doi:10.1038/366687a0. short: Y. Hayashi, A. Momiyama, T. Takahashi, H. Ohishi, R. Ogawa Meguro, R. Shigemoto, N. Mizuno, S. Nakanishi, Nature 366 (1993) 687–690. date_created: 2018-12-11T11:58:18Z date_published: 1993-01-01T00:00:00Z date_updated: 2022-03-31T09:36:00Z day: '01' doi: 10.1038/366687a0 extern: '1' external_id: pmid: - '7903116 ' intvolume: ' 366' issue: '6456' language: - iso: eng main_file_link: - url: https://www.nature.com/articles/366687a0 month: '01' oa_version: None page: 687 - 690 pmid: 1 publication: Nature publication_identifier: issn: - 0028-0836 publication_status: published publisher: Nature Publishing Group publist_id: '4354' quality_controlled: '1' scopus_import: '1' status: public title: Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 366 year: '1993' ...