Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split

Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, S. Nakanishi, Genes and Development 6 (1992) 2620–2634.

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Abstract
We report the molecular characterization of two novel rat helix-loop-helix (HLH) proteins, designated HES-1 and HES-3, that show structural homology to the Drosophila hairy and Enhancer of split [E(spl)] proteins, both of which are required for normal neurogenesis. HES-1 mRNA, expressed in various tissues of both embryos and adults, is present at a high level in the epithelial cells, including the embryonal neuroepithelial cells, as well as in the mesoderm-derived tissues such as the embryonal muscle. In contrast, HES-3 mRNA is produced exclusively in cerebellar Purkinje cells. HES-1 represses transcription by binding to the N box, which is a recognition sequence of E(spl) proteins. Interestingly, neither HES-1 nor HES-3 alone interacts efficiently with the E box, but each protein decreases the transcription induced by E-box-binding HLH activators such as E47. Furthermore, HES-1 also inhibits the functions of MyoD and MASH1 and effectively diminishes the myogenic conversion of C3H10T1/2 cells induced by MyoD. These results suggest that HES-1 may play an important role in mammalian development by negatively acting on the two different sequences while HES-3 acts as a repressor in a specific type of neurons.
Publishing Year
Date Published
1992-01-01
Journal Title
Genes and Development
Volume
6
Issue
12 B
Page
2620 - 2634
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Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes and Development. 1992;6(12 B):2620-2634. doi:10.1101/gad.6.12b.2620
Sasai, Y., Kageyama, R., Tagawa, Y., Shigemoto, R., & Nakanishi, S. (1992). Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes and Development, 6(12 B), 2620–2634. https://doi.org/10.1101/gad.6.12b.2620
Sasai, Yoshiki, Ryoichiro Kageyama, Yoshiaki Tagawa, Ryuichi Shigemoto, and Shigetada Nakanishi. “Two Mammalian Helix-Loop-Helix Factors Structurally Related to Drosophila Hairy and Enhancer of Split.” Genes and Development 6, no. 12 B (1992): 2620–34. https://doi.org/10.1101/gad.6.12b.2620.
Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, and S. Nakanishi, “Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split,” Genes and Development, vol. 6, no. 12 B, pp. 2620–2634, 1992.
Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. 1992. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes and Development. 6(12 B), 2620–2634.
Sasai, Yoshiki, et al. “Two Mammalian Helix-Loop-Helix Factors Structurally Related to Drosophila Hairy and Enhancer of Split.” Genes and Development, vol. 6, no. 12 B, Cold Spring Harbor Laboratory Press, 1992, pp. 2620–34, doi:10.1101/gad.6.12b.2620.

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