---
_id: '2534'
abstract:
- lang: eng
text: Vasoactive intestinal polypeptide (VIP), a 28 amino acid peptide hormone,
plays many physiological roles in the peripheral and central nerve systems. A
functional cDNA clone of the VIP receptor was isolated from a rat lung cDNA library
by cross-hybridization with the secretin receptor cDNA. VIP bound the cloned VIP
receptor expressed in mouse COP cells and stimulated adenylate cyclase through
the cloned receptor. The rat VIP receptor consists of 459 amino acids with a calculated
Mr of 52,054 and contains seven transmembrane segments. It is structurally related
to the secretin, calcitonin, and parathyroid hormone receptors, suggesting that
they constitute a new subfamily of the G5 protein - coupled receptors. VIP receptor
mRNA was detected in various rat tissues including liver, lung, intestines, and
brain. In situ hybridization revealed that VIP receptor mRNA is widely distributed
in neuronal cells of the adult rat brain, with a relatively high expression in
the cerebral cortex and hippocampus.
acknowledgement: "We thank Drs. R. Yoshida, K. Katoh, and K. lmamura for help with
the in situ hybridization, Dr. M. Nishizawa for discussion, and Ms. M. lkeda for
secretarial assistance. This work was supported in part by a Grant-in-Aid from the
Ministry of Education, Science and Culture of Japan. The costs of publication of
this article were defrayed in part\r\nby the payment of page charges. This article
must therefore be hereby marked “advertisement” in accordance with 18 USC Section
1734 solely to indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Takeshi
full_name: Ishihara, Takeshi
last_name: Ishihara
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kensaku
full_name: Mori, Kensaku
last_name: Mori
- first_name: Kenji
full_name: Takahashi, Kenji
last_name: Takahashi
- first_name: Shigekazu
full_name: Nagata, Shigekazu
last_name: Nagata
citation:
ama: Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. Functional expression
and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.
Neuron. 1992;8(4):811-819. doi:10.1016/0896-6273(92)90101-I
apa: Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K., & Nagata, S. (1992).
Functional expression and tissue distribution of a novel receptor for vasoactive
intestinal polypeptide. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(92)90101-I
chicago: Ishihara, Takeshi, Ryuichi Shigemoto, Kensaku Mori, Kenji Takahashi, and
Shigekazu Nagata. “Functional Expression and Tissue Distribution of a Novel Receptor
for Vasoactive Intestinal Polypeptide.” Neuron. Elsevier, 1992. https://doi.org/10.1016/0896-6273(92)90101-I.
ieee: T. Ishihara, R. Shigemoto, K. Mori, K. Takahashi, and S. Nagata, “Functional
expression and tissue distribution of a novel receptor for vasoactive intestinal
polypeptide,” Neuron, vol. 8, no. 4. Elsevier, pp. 811–819, 1992.
ista: Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. 1992. Functional expression
and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.
Neuron. 8(4), 811–819.
mla: Ishihara, Takeshi, et al. “Functional Expression and Tissue Distribution of
a Novel Receptor for Vasoactive Intestinal Polypeptide.” Neuron, vol. 8,
no. 4, Elsevier, 1992, pp. 811–19, doi:10.1016/0896-6273(92)90101-I.
short: T. Ishihara, R. Shigemoto, K. Mori, K. Takahashi, S. Nagata, Neuron 8 (1992)
811–819.
date_created: 2018-12-11T11:58:14Z
date_published: 1992-04-01T00:00:00Z
date_updated: 2022-03-17T13:33:07Z
day: '01'
doi: 10.1016/0896-6273(92)90101-I
extern: '1'
external_id:
pmid:
- '1314625'
intvolume: ' 8'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/089662739290101I?via%3Dihub
month: '04'
oa_version: None
page: 811 - 819
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4363'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional expression and tissue distribution of a novel receptor for vasoactive
intestinal polypeptide
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 8
year: '1992'
...