---
_id: '2508'
abstract:
- lang: eng
text: 'The activity patterns of subthalamic nucleus (STN) neurons are intimately
linked to motor function and dysfunction and arise through the complex interaction
of intrinsic properties and inhibitory and excitatory synaptic inputs. In many
neurons, hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play
key roles in intrinsic excitability and synaptic integration both under normal
conditions and in disease states. However, in STN neurons, which strongly express
HCN channels, their roles remain relatively obscure. To address this deficit,
complementary molecular and cellular electrophysiological, imaging, and computational
approaches were applied to the rat STN. Molecular profiling demonstrated that
individual STN neurons express mRNA encoding several HCN subunits, with HCN2 and
3 being the most abundant. Light and electron microscopic analysis showed that
HCN2 subunits are strongly expressed and distributed throughout the somatodendritic
plasma membrane. Voltage-, current-, and dynamic-clamp analysis, two-photon Ca
2+ imaging, and computational modeling revealed that HCN channels are activated
by GABA A receptor-mediated inputs and thus limit synaptic hyperpolarization and
deinactivation of low-voltage-activated Ca 2+ channels. Although HCN channels
also limited the temporal summation of EPSPs, generated through two-photon uncaging
of glutamate, this action was largely shunted by GABAergic inhibition that was
necessary for HCN channel activation. Together the data demonstrate that HCN channels
in STN neurons selectively counteract GABA A receptor-mediated inhibition arising
from the globus pallidus and thus promote single-spike activity rather than rebound
burst firing. '
author:
- first_name: Jeremy
full_name: Atherton, Jeremy F
last_name: Atherton
- first_name: Katsunori
full_name: Kitano, Katsunori
last_name: Kitano
- first_name: Jérôme
full_name: Baufreton, Jérôme
last_name: Baufreton
- first_name: Kai
full_name: Fan, Kai
last_name: Fan
- first_name: David
full_name: Wokosin, David L
last_name: Wokosin
- first_name: Tatiana
full_name: Tkatch, Tatiana
last_name: Tkatch
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: James
full_name: Surmeier, James D
last_name: Surmeier
- first_name: Mark
full_name: Bevan, Mark D
last_name: Bevan
citation:
ama: Atherton J, Kitano K, Baufreton J, et al. Selective participation of somatodendritic
HCN channels in inhibitory but not excitatory synaptic integration in neurons
of the subthalamic nucleus. Journal of Neuroscience. 2010;30(47):16025-16040.
doi:10.1523/JNEUROSCI.3898-10.2010
apa: Atherton, J., Kitano, K., Baufreton, J., Fan, K., Wokosin, D., Tkatch, T.,
… Bevan, M. (2010). Selective participation of somatodendritic HCN channels in
inhibitory but not excitatory synaptic integration in neurons of the subthalamic
nucleus. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.3898-10.2010
chicago: Atherton, Jeremy, Katsunori Kitano, Jérôme Baufreton, Kai Fan, David Wokosin,
Tatiana Tkatch, Ryuichi Shigemoto, James Surmeier, and Mark Bevan. “Selective
Participation of Somatodendritic HCN Channels in Inhibitory but Not Excitatory
Synaptic Integration in Neurons of the Subthalamic Nucleus.” Journal of Neuroscience.
Society for Neuroscience, 2010. https://doi.org/10.1523/JNEUROSCI.3898-10.2010.
ieee: J. Atherton et al., “Selective participation of somatodendritic HCN
channels in inhibitory but not excitatory synaptic integration in neurons of the
subthalamic nucleus,” Journal of Neuroscience, vol. 30, no. 47. Society
for Neuroscience, pp. 16025–16040, 2010.
ista: Atherton J, Kitano K, Baufreton J, Fan K, Wokosin D, Tkatch T, Shigemoto R,
Surmeier J, Bevan M. 2010. Selective participation of somatodendritic HCN channels
in inhibitory but not excitatory synaptic integration in neurons of the subthalamic
nucleus. Journal of Neuroscience. 30(47), 16025–16040.
mla: Atherton, Jeremy, et al. “Selective Participation of Somatodendritic HCN Channels
in Inhibitory but Not Excitatory Synaptic Integration in Neurons of the Subthalamic
Nucleus.” Journal of Neuroscience, vol. 30, no. 47, Society for Neuroscience,
2010, pp. 16025–40, doi:10.1523/JNEUROSCI.3898-10.2010.
short: J. Atherton, K. Kitano, J. Baufreton, K. Fan, D. Wokosin, T. Tkatch, R. Shigemoto,
J. Surmeier, M. Bevan, Journal of Neuroscience 30 (2010) 16025–16040.
date_created: 2018-12-11T11:58:05Z
date_published: 2010-11-24T00:00:00Z
date_updated: 2021-01-12T06:57:54Z
day: '24'
doi: 10.1523/JNEUROSCI.3898-10.2010
extern: 1
intvolume: ' 30'
issue: '47'
month: '11'
page: 16025 - 16040
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '4393'
quality_controlled: 0
status: public
title: Selective participation of somatodendritic HCN channels in inhibitory but not
excitatory synaptic integration in neurons of the subthalamic nucleus
type: journal_article
volume: 30
year: '2010'
...