Rives, Marie L; Vol, Claire; Fukazawa, Yugo; Tinel, Norbert; Trinquet, Eric; Ayoub, Mohammed A; Shigemoto, RyuichiIST Austria ; Pin, Jean-Philippe; Prezèau, Laurent
G protein-coupled receptors (GPCRs) have critical functions in intercellular communication. Although a wide range of different receptors have been identified in the same cells, the mechanism by which signals are integrated remains elusive. The ability of GPCRs to form dimers or larger hetero-oligomers is thought to generate such signal integration. We examined the molecular mechanisms responsible for the GABAB receptor-mediated potentiation of the mGlu receptor signalling reported in Purkinje neurons. We showed that this effect does not require a physical interaction between both receptors. Instead, it is the result of a more general mechanism in which the βγ subunits produced by the Gi-coupled GABAB receptor enhance the mGlu-mediated Gq response. Most importantly, this mechanism could be generally applied to other pairs of Gi- and Gq-coupled receptors and the signal integration varied depending on the time delay between activation of each receptor. Such a mechanism helps explain specific properties of cells expressing two different Gi- and Gq-coupled receptors activated by a single transmitter, or properties of GPCRs naturally coupled to both types of the G protein.
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Rives M, Vol C, Fukazawa Y, et al. Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. EMBO Journal. 2009;28(15):2195-2208. doi:10.1038/emboj.2009.177
Rives, M., Vol, C., Fukazawa, Y., Tinel, N., Trinquet, E., Ayoub, M., … Prezèau, L. (2009). Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. EMBO Journal, 28(15), 2195–2208. https://doi.org/10.1038/emboj.2009.177
Rives, Marie, Claire Vol, Yugo Fukazawa, Norbert Tinel, Eric Trinquet, Mohammed Ayoub, Ryuichi Shigemoto, Jean Pin, and Laurent Prezèau. “Crosstalk between GABAB and MGlu1a Receptors Reveals New Insight into GPCR Signal Integration.” EMBO Journal 28, no. 15 (2009): 2195–2208. https://doi.org/10.1038/emboj.2009.177.
M. Rives et al., “Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration,” EMBO Journal, vol. 28, no. 15, pp. 2195–2208, 2009.
Rives M, Vol C, Fukazawa Y, Tinel N, Trinquet E, Ayoub M, Shigemoto R, Pin J, Prezèau L. 2009. Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. EMBO Journal. 28(15), 2195–2208.
Rives, Marie, et al. “Crosstalk between GABAB and MGlu1a Receptors Reveals New Insight into GPCR Signal Integration.” EMBO Journal, vol. 28, no. 15, Wiley-Blackwell, 2009, pp. 2195–208, doi:10.1038/emboj.2009.177.
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