---
_id: '2496'
abstract:
- lang: eng
text: 'Glutamate is one candidate for the neurotransmitters and/or neuromodulators
involved in taste signaling in taste buds. Group II metabotropic glutamate receptors
(mGluRs: mGluR2 and mGluR3) are known to function as presynaptic receptors that
regulate the release of glutamate and/or other neurotransmitters in the central
nervous system. Group II mGluRs are negatively linked to adenylyl cyclase through
Gαi subunits and thereby reduce the turnover of cAMP. In rat taste tissues, a
subset of adenylyl-cyclase-8-expressing taste cells coexpress the Gαi subunits
gustducin and Gαi2. However, the expression patterns of group II mGluRs in rat
taste tissues have not yet been elucidated. We have therefore examined the expression
patterns of mGluR2, mGluR3, and gustducin in rat gustatory tissues. Reverse transcription/polymerase
chain reaction assays have revealed that mGluR2 and mGluR3 mRNAs are expressed
in the circumvallate papillae. In situ hybridization analyses have detected positive
signals for mGluR2 and mGluR3 mRNAs only in the circumvallate taste buds. Among
the fungiform, foliate, and circumvallate papillae, an antibody against mGluR2/3
labels a subset of taste bud cells and nerve fibers immediately beneath the taste
lingual epithelium. Double-labeling experiments have demonstrated that mGluR2/3-positive
cells coexpress gustducin. These results indicate that mGluR2 and mGluR3 are coupled
to Gαi subunits and play roles in glutamate-mediated signaling in taste transductions.'
author:
- first_name: Takashi
full_name: Toyono, Takashi
last_name: Toyono
- first_name: Shinji
full_name: Kataoka, Shinji
last_name: Kataoka
- first_name: Yuji
full_name: Seta, Yuji
last_name: Seta
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kuniaki
full_name: Toyoshima, Kuniaki
last_name: Toyoshima
citation:
ama: Toyono T, Kataoka S, Seta Y, Shigemoto R, Toyoshima K. Expression of group
II metabotropic glutamate receptors in rat gustatory papillae. Cell and Tissue
Research. 2007;328(1):57-63. doi:10.1007/s00441-006-0351-9
apa: Toyono, T., Kataoka, S., Seta, Y., Shigemoto, R., & Toyoshima, K. (2007).
Expression of group II metabotropic glutamate receptors in rat gustatory papillae.
Cell and Tissue Research. Springer. https://doi.org/10.1007/s00441-006-0351-9
chicago: Toyono, Takashi, Shinji Kataoka, Yuji Seta, Ryuichi Shigemoto, and Kuniaki
Toyoshima. “Expression of Group II Metabotropic Glutamate Receptors in Rat Gustatory
Papillae.” Cell and Tissue Research. Springer, 2007. https://doi.org/10.1007/s00441-006-0351-9.
ieee: T. Toyono, S. Kataoka, Y. Seta, R. Shigemoto, and K. Toyoshima, “Expression
of group II metabotropic glutamate receptors in rat gustatory papillae,” Cell
and Tissue Research, vol. 328, no. 1. Springer, pp. 57–63, 2007.
ista: Toyono T, Kataoka S, Seta Y, Shigemoto R, Toyoshima K. 2007. Expression of
group II metabotropic glutamate receptors in rat gustatory papillae. Cell and
Tissue Research. 328(1), 57–63.
mla: Toyono, Takashi, et al. “Expression of Group II Metabotropic Glutamate Receptors
in Rat Gustatory Papillae.” Cell and Tissue Research, vol. 328, no. 1,
Springer, 2007, pp. 57–63, doi:10.1007/s00441-006-0351-9.
short: T. Toyono, S. Kataoka, Y. Seta, R. Shigemoto, K. Toyoshima, Cell and Tissue
Research 328 (2007) 57–63.
date_created: 2018-12-11T11:58:00Z
date_published: 2007-04-01T00:00:00Z
date_updated: 2021-01-12T06:57:50Z
day: '01'
doi: 10.1007/s00441-006-0351-9
extern: 1
intvolume: ' 328'
issue: '1'
month: '04'
page: 57 - 63
publication: Cell and Tissue Research
publication_status: published
publisher: Springer
publist_id: '4405'
quality_controlled: 0
status: public
title: Expression of group II metabotropic glutamate receptors in rat gustatory papillae
type: journal_article
volume: 328
year: '2007'
...