{"month":"09","article_type":"original","publication_identifier":{"issn":["0021-9967"]},"pmid":1,"oa_version":"None","year":"1994","acknowledgement":"We are grateful to  Mr.  Akira  Uesugi for photographic help and for the support of Drs. Satoru Fukuchi, Toshio Fukuda, Ritsu Hayashi, Mizuho Katsurada, Yutaka Kitani, Keiko Kumagai,  Toshihiko Kuroda,  Hiroshi  Matsubara, Hiroshi Matsushima, Chisato Minakuchi, Masatoshi Nishio, Gonpei  Niwa Hajime Oda, Masahiko  Ohbayashi, Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watan- abe, Kazuo Yoshino, and Toshiaki Yoshino. This work was supported in part by research grants from the Ministry of Education, Science and Culture of Japan.","main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1002/cne.903470112"}],"external_id":{"pmid":["7798379"]},"date_published":"1994-09-01T00:00:00Z","language":[{"iso":"eng"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"1","date_created":"2018-12-11T11:57:58Z","quality_controlled":"1","extern":"1","abstract":[{"text":"Five N-methyl-D-aspartate (NMDA) receptor subunits have been identified thus far: NR1, NR2A, NR2B, NR2C, and NR2D. Here, we have analyzed the expression patterns of mRNAs for the NMDA receptor subunits in the developing and adult rats by in situ hybridization. The developmental changes of the expression patterns were most salient in the cerebellum. In the external granular layer, hybridization signals of mRNAs for NR1, NR2A, NR2B, and NR2C appeared by postnatal day 3, but no NR2D mRNA was expressed at any developmental stage examined. The NR1 mRNA was expressed in all cerebellar neurons at all developmental stages examined. The signals for the NR2A mRNA appeared in Purkinje cells and granule cells during the second postnatal week. The signals for the NR2B mRNA in granule cells were seen transiently during the first 2 weeks after birth. The signals for NR2C mRNA appeared in granule cells and glial cells during the second postnatal week. The signals for NR2D mRNA appeared transiently in Purkinje cells during the first 8 postnatal days; in adult rats, these were seen in stellate and Golgi cells. In the cerebellar nuclei, mRNAs for NR1, NR2A, NR2B, and NR2D were more or less expressed on postnatal day 0, while expression signals for the NR2C mRNA were first detected in postnatal day 14. Thus, the most conspicuous changes of expression patterns were observed in the cerebellar cortex during the first 2 weeks after birth, when development and maturation of the cerebellum proceed most rapidly.","lang":"eng"}],"date_updated":"2022-06-09T12:11:20Z","publication_status":"published","publisher":"Wiley-Blackwell","title":"Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats","intvolume":"       347","publist_id":"4412","type":"journal_article","status":"public","citation":{"ista":"Akazawa C, Shigemoto R, Bessho Y, Nakanishi S, Mizuno N. 1994. Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. Journal of Comparative Neurology. 347(1), 150–160.","ama":"Akazawa C, Shigemoto R, Bessho Y, Nakanishi S, Mizuno N. Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. <i>Journal of Comparative Neurology</i>. 1994;347(1):150-160. doi:<a href=\"https://doi.org/10.1002/cne.903470112\">10.1002/cne.903470112</a>","mla":"Akazawa, Chihiro, et al. “Differential Expression of Five N-Methyl-D-Aspartate Receptor Subunit MRNAs in the Cerebellum of Developing and Adult Rats.” <i>Journal of Comparative Neurology</i>, vol. 347, no. 1, Wiley-Blackwell, 1994, pp. 150–60, doi:<a href=\"https://doi.org/10.1002/cne.903470112\">10.1002/cne.903470112</a>.","ieee":"C. Akazawa, R. Shigemoto, Y. Bessho, S. Nakanishi, and N. Mizuno, “Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats,” <i>Journal of Comparative Neurology</i>, vol. 347, no. 1. Wiley-Blackwell, pp. 150–160, 1994.","short":"C. Akazawa, R. Shigemoto, Y. Bessho, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 347 (1994) 150–160.","chicago":"Akazawa, Chihiro, Ryuichi Shigemoto, Yasumasa Bessho, Shigetada Nakanishi, and Noboru Mizuno. “Differential Expression of Five N-Methyl-D-Aspartate Receptor Subunit MRNAs in the Cerebellum of Developing and Adult Rats.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 1994. <a href=\"https://doi.org/10.1002/cne.903470112\">https://doi.org/10.1002/cne.903470112</a>.","apa":"Akazawa, C., Shigemoto, R., Bessho, Y., Nakanishi, S., &#38; Mizuno, N. (1994). Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.903470112\">https://doi.org/10.1002/cne.903470112</a>"},"page":"150 - 160","publication":"Journal of Comparative Neurology","scopus_import":"1","volume":347,"_id":"2489","author":[{"last_name":"Akazawa","full_name":"Akazawa, Chihiro","first_name":"Chihiro"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi"},{"first_name":"Yasumasa","full_name":"Bessho, Yasumasa","last_name":"Bessho"},{"first_name":"Shigetada","full_name":"Nakanishi, Shigetada","last_name":"Nakanishi"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"}],"day":"01","article_processing_charge":"No","doi":"10.1002/cne.903470112"}