A family of metabotropic glutamate receptors

Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, S. Nakanishi, Neuron 8 (1992) 169–179.

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Abstract
Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA- transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.
Publishing Year
Date Published
1992-01-01
Journal Title
Neuron
Volume
8
Issue
1
Page
169 - 179
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Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 1992;8(1):169-179. doi:10.1016/0896-6273(92)90118-W
Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., & Nakanishi, S. (1992). A family of metabotropic glutamate receptors. Neuron, 8(1), 169–179. https://doi.org/10.1016/0896-6273(92)90118-W
Tanabe, Yasuto, Masayuki Masu, Takahiro Ishii, Ryuichi Shigemoto, and Shigetada Nakanishi. “A Family of Metabotropic Glutamate Receptors.” Neuron 8, no. 1 (1992): 169–79. https://doi.org/10.1016/0896-6273(92)90118-W.
Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, and S. Nakanishi, “A family of metabotropic glutamate receptors,” Neuron, vol. 8, no. 1, pp. 169–179, 1992.
Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. 1992. A family of metabotropic glutamate receptors. Neuron. 8(1), 169–179.
Tanabe, Yasuto, et al. “A Family of Metabotropic Glutamate Receptors.” Neuron, vol. 8, no. 1, Elsevier, 1992, pp. 169–79, doi:10.1016/0896-6273(92)90118-W.

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