---
_id: '2474'
abstract:
- lang: eng
text: 'Interneurons are critical for neuronal circuit function, but how their dendritic
morphologies and membrane properties influence information flow within neuronal
circuits is largely unknown. We studied the spatiotemporal profile of synaptic
integration and short-term plasticity in dendrites of mature cerebellar stellate
cells by combining two-photon guided electrical stimulation, glutamate uncaging,
electron microscopy, and modeling. Synaptic activation within thin (0.4 μm) dendrites
produced somatic responses that became smaller and slower with increasing distance
from the soma, sublinear subthreshold input-output relationships, and a somatodendritic
gradient of short-term plasticity. Unlike most studies showing that neurons employ
active dendritic mechanisms, we found that passive cable properties of thin dendrites
determine the sublinear integration and plasticity gradient, which both result
from large dendritic depolarizations that reduce synaptic driving force. These
integrative properties allow stellate cells to act as spatiotemporal filters of
synaptic input patterns, thereby biasing their output in favor of sparse presynaptic
activity. Stellate cells are critical sources of inhibition in the cerebellum,
but how their dendrites integrate excitatory synaptic inputs is unknown. Abrahamsson
et al. show that thin dendrites and passive membrane properties of SCs promote
sublinear synaptic summation and distance-dependent short-term plasticity. '
author:
- first_name: Therese
full_name: Abrahamsson, Therese
last_name: Abrahamsson
- first_name: Laurence
full_name: Cathala, Laurence
last_name: Cathala
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: David
full_name: DiGregorio, David A
last_name: Digregorio
citation:
ama: Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. Thin dendrites
of cerebellar interneurons confer sublinear synaptic integration and a gradient
of short-term plasticity. Neuron. 2012;73(6):1159-1172. doi:10.1016/j.neuron.2012.01.027
apa: Abrahamsson, T., Cathala, L., Matsui, K., Shigemoto, R., & Digregorio,
D. (2012). Thin dendrites of cerebellar interneurons confer sublinear synaptic
integration and a gradient of short-term plasticity. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2012.01.027
chicago: Abrahamsson, Therese, Laurence Cathala, Ko Matsui, Ryuichi Shigemoto, and
David Digregorio. “Thin Dendrites of Cerebellar Interneurons Confer Sublinear
Synaptic Integration and a Gradient of Short-Term Plasticity.” Neuron.
Elsevier, 2012. https://doi.org/10.1016/j.neuron.2012.01.027.
ieee: T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, and D. Digregorio, “Thin
dendrites of cerebellar interneurons confer sublinear synaptic integration and
a gradient of short-term plasticity,” Neuron, vol. 73, no. 6. Elsevier,
pp. 1159–1172, 2012.
ista: Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. 2012. Thin
dendrites of cerebellar interneurons confer sublinear synaptic integration and
a gradient of short-term plasticity. Neuron. 73(6), 1159–1172.
mla: Abrahamsson, Therese, et al. “Thin Dendrites of Cerebellar Interneurons Confer
Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity.” Neuron,
vol. 73, no. 6, Elsevier, 2012, pp. 1159–72, doi:10.1016/j.neuron.2012.01.027.
short: T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, D. Digregorio, Neuron
73 (2012) 1159–1172.
date_created: 2018-12-11T11:57:52Z
date_published: 2012-03-22T00:00:00Z
date_updated: 2021-01-12T06:57:42Z
day: '22'
doi: 10.1016/j.neuron.2012.01.027
extern: 1
intvolume: ' 73'
issue: '6'
month: '03'
page: 1159 - 1172
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '4427'
quality_controlled: 0
status: public
title: Thin dendrites of cerebellar interneurons confer sublinear synaptic integration
and a gradient of short-term plasticity
type: journal_article
volume: 73
year: '2012'
...