Inter-regulation of the unfolded protein response and auxin signaling

Y. Chen, K. Aung, J. Rolčík, K. Walicki, J. Friml, F. Brandizzí, Plant Journal 77 (2014) 97–107.


Journal Article | Published | English
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Abstract
The unfolded protein response (UPR) is a signaling network triggered by overload of protein-folding demand in the endoplasmic reticulum (ER), a condition termed ER stress. The UPR is critical for growth and development; nonetheless, connections between the UPR and other cellular regulatory processes remain largely unknown. Here, we identify a link between the UPR and the phytohormone auxin, a master regulator of plant physiology. We show that ER stress triggers down-regulation of auxin receptors and transporters in Arabidopsis thaliana. We also demonstrate that an Arabidopsis mutant of a conserved ER stress sensor IRE1 exhibits defects in the auxin response and levels. These data not only support that the plant IRE1 is required for auxin homeostasis, they also reveal a species-specific feature of IRE1 in multicellular eukaryotes. Furthermore, by establishing that UPR activation is reduced in mutants of ER-localized auxin transporters, including PIN5, we define a long-neglected biological significance of ER-based auxin regulation. We further examine the functional relationship of IRE1 and PIN5 by showing that an ire1 pin5 triple mutant enhances defects of UPR activation and auxin homeostasis in ire1 or pin5. Our results imply that the plant UPR has evolved a hormone-dependent strategy for coordinating ER function with physiological processes.
Publishing Year
Date Published
2014-01-01
Journal Title
Plant Journal
Volume
77
Issue
1
Page
97 - 107
ISSN
IST-REx-ID

Cite this

Chen Y, Aung K, Rolčík J, Walicki K, Friml J, Brandizzí F. Inter-regulation of the unfolded protein response and auxin signaling. Plant Journal. 2014;77(1):97-107. doi:10.1111/tpj.12373
Chen, Y., Aung, K., Rolčík, J., Walicki, K., Friml, J., & Brandizzí, F. (2014). Inter-regulation of the unfolded protein response and auxin signaling. Plant Journal, 77(1), 97–107. https://doi.org/10.1111/tpj.12373
Chen, Yani, Kyaw Aung, Jakub Rolčík, Kathryn Walicki, Jirí Friml, and Federica Brandizzí. “Inter-Regulation of the Unfolded Protein Response and Auxin Signaling.” Plant Journal 77, no. 1 (2014): 97–107. https://doi.org/10.1111/tpj.12373.
Y. Chen, K. Aung, J. Rolčík, K. Walicki, J. Friml, and F. Brandizzí, “Inter-regulation of the unfolded protein response and auxin signaling,” Plant Journal, vol. 77, no. 1, pp. 97–107, 2014.
Chen Y, Aung K, Rolčík J, Walicki K, Friml J, Brandizzí F. 2014. Inter-regulation of the unfolded protein response and auxin signaling. Plant Journal. 77(1), 97–107.
Chen, Yani, et al. “Inter-Regulation of the Unfolded Protein Response and Auxin Signaling.” Plant Journal, vol. 77, no. 1, Wiley-Blackwell, 2014, pp. 97–107, doi:10.1111/tpj.12373.

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