Progress and prospects toward our understanding of the evolution of dosage compensation

B. Vicoso, D. Bachtrog, Chromosome Research 17 (2009) 585–602.

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Journal Article | Published
Author
Vicoso, BeatrizIST Austria ; Bachtrog, Doris
Abstract
In many eukaryotic organisms, gender is determined by a pair of heteromorphic sex chromosomes. Degeneration of the non-recombining Y chromosome is a general facet of sex chromosome evolution. Selective pressure to restore expression levels of X-linked genes relative to autosomes accompanies Y-chromosome degeneration, thus driving the evolution of dosage compensation mechanisms. This review focuses on evolutionary aspects of dosage compensation, in light of recent advances in comparative and functional genomics that have substantially increased our understanding of the molecular mechanisms of dosage compensation and how it evolved. We review processes involved in sex chromosome evolution, and discuss the dynamic interaction between Y degeneration and the acquisition of dosage compensation. We compare mechanisms of dosage compensation and the origin of dosage compensation genes between different taxa and comment on sex chromosomes that apparently lack compensation mechanisms. Finally, we discuss how dosage compensation systems can also influence the evolution of well-established sex chromosomes.
Publishing Year
Date Published
2009-07-01
Journal Title
Chromosome Research
Acknowledgement
This research is funded by NIH Grant GM076007 and a Sloan Research Fellowship and a David and Lucile Packard Fellowship to D.B.
Volume
17
Issue
5
Page
585 - 602
IST-REx-ID

Cite this

Vicoso B, Bachtrog D. Progress and prospects toward our understanding of the evolution of dosage compensation. Chromosome Research. 2009;17(5):585-602. doi:10.1007/s10577-009-9053-y
Vicoso, B., & Bachtrog, D. (2009). Progress and prospects toward our understanding of the evolution of dosage compensation. Chromosome Research, 17(5), 585–602. https://doi.org/10.1007/s10577-009-9053-y
Vicoso, Beatriz, and Doris Bachtrog. “Progress and Prospects toward Our Understanding of the Evolution of Dosage Compensation.” Chromosome Research 17, no. 5 (2009): 585–602. https://doi.org/10.1007/s10577-009-9053-y.
B. Vicoso and D. Bachtrog, “Progress and prospects toward our understanding of the evolution of dosage compensation,” Chromosome Research, vol. 17, no. 5, pp. 585–602, 2009.
Vicoso B, Bachtrog D. 2009. Progress and prospects toward our understanding of the evolution of dosage compensation. Chromosome Research. 17(5), 585–602.
Vicoso, Beatriz, and Doris Bachtrog. “Progress and Prospects toward Our Understanding of the Evolution of Dosage Compensation.” Chromosome Research, vol. 17, no. 5, Springer, 2009, pp. 585–602, doi:10.1007/s10577-009-9053-y.

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