{"publisher":"Springer","publist_id":"4970","abstract":[{"text":"In Drosophila, there is a consistent deficit of male-biased genes on the X chromosome. It has been suggested that male-biased genes may evolve from initially unbiased genes as a result of increased expression levels in males. If transcription rates are limited, a large increase in expression in the testis may be harder to achieve for single-copy X-linked genes than for autosomal genes, because they are already hypertranscribed due to dosage compensation. This hypothesis predicts that the larger the increase in expression required to make a male-biased gene, the lower the chance of this being achievable if it is located on the X chromosome. Consequently, highly expressed male-biased genes should be located on the X chromosome less often than lowly expressed male-biased genes. This pattern is observed in our analysis of publicly available data, where microarray data or EST data are used to detect male-biased genes in D. melanogaster and to measure their expression levels. This is consistent with the idea that limitations in transcription rates may prevent male-biased genes from accumulating on the X chromosome.","lang":"eng"}],"extern":1,"issue":"5","intvolume":"        68","doi":"10.1007/s00239-009-9235-4","acknowledgement":"This work was funded by a Portuguese Foundation for Science and Technology scholarship to B.V., and B.C. was supported by the Royal Society","publication_status":"published","citation":{"short":"B. Vicoso, B. Charlesworth, Journal of Molecular Evolution 68 (2009) 576–583.","apa":"Vicoso, B., &#38; Charlesworth, B. (2009). The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation? <i>Journal of Molecular Evolution</i>. Springer. <a href=\"https://doi.org/10.1007/s00239-009-9235-4\">https://doi.org/10.1007/s00239-009-9235-4</a>","ista":"Vicoso B, Charlesworth B. 2009. The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation? Journal of Molecular Evolution. 68(5), 576–583.","mla":"Vicoso, Beatriz, and Brian Charlesworth. “The Deficit of Male-Biased Genes on the D. Melanogaster X Chromosome Is Expression-Dependent: A Consequence of Dosage Compensation?” <i>Journal of Molecular Evolution</i>, vol. 68, no. 5, Springer, 2009, pp. 576–83, doi:<a href=\"https://doi.org/10.1007/s00239-009-9235-4\">10.1007/s00239-009-9235-4</a>.","chicago":"Vicoso, Beatriz, and Brian Charlesworth. “The Deficit of Male-Biased Genes on the D. Melanogaster X Chromosome Is Expression-Dependent: A Consequence of Dosage Compensation?” <i>Journal of Molecular Evolution</i>. Springer, 2009. <a href=\"https://doi.org/10.1007/s00239-009-9235-4\">https://doi.org/10.1007/s00239-009-9235-4</a>.","ieee":"B. Vicoso and B. Charlesworth, “The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation?,” <i>Journal of Molecular Evolution</i>, vol. 68, no. 5. Springer, pp. 576–583, 2009.","ama":"Vicoso B, Charlesworth B. The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation? <i>Journal of Molecular Evolution</i>. 2009;68(5):576-583. doi:<a href=\"https://doi.org/10.1007/s00239-009-9235-4\">10.1007/s00239-009-9235-4</a>"},"year":"2009","day":"01","type":"journal_article","status":"public","author":[{"orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","last_name":"Vicoso","full_name":"Beatriz Vicoso"},{"first_name":"Brian","last_name":"Charlesworth","full_name":"Charlesworth, Brian"}],"date_published":"2009-05-01T00:00:00Z","_id":"2068","title":"The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation?","quality_controlled":0,"date_created":"2018-12-11T11:55:31Z","publication":"Journal of Molecular Evolution","month":"05","date_updated":"2021-01-12T06:55:06Z","page":"576 - 583","volume":68}