--- res: bibo_abstract: - In Drosophila, there is a consistent deficit of male-biased genes on the X chromosome. It has been suggested that male-biased genes may evolve from initially unbiased genes as a result of increased expression levels in males. If transcription rates are limited, a large increase in expression in the testis may be harder to achieve for single-copy X-linked genes than for autosomal genes, because they are already hypertranscribed due to dosage compensation. This hypothesis predicts that the larger the increase in expression required to make a male-biased gene, the lower the chance of this being achievable if it is located on the X chromosome. Consequently, highly expressed male-biased genes should be located on the X chromosome less often than lowly expressed male-biased genes. This pattern is observed in our analysis of publicly available data, where microarray data or EST data are used to detect male-biased genes in D. melanogaster and to measure their expression levels. This is consistent with the idea that limitations in transcription rates may prevent male-biased genes from accumulating on the X chromosome.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Beatriz foaf_name: Beatriz Vicoso foaf_surname: Vicoso foaf_workInfoHomepage: http://www.librecat.org/personId=49E1C5C6-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-4579-8306 - foaf_Person: foaf_givenName: Brian foaf_name: Charlesworth, Brian foaf_surname: Charlesworth bibo_doi: 10.1007/s00239-009-9235-4 bibo_issue: '5' bibo_volume: 68 dct_date: 2009^xs_gYear dct_publisher: Springer@ dct_title: 'The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation?@' ...