The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation?

B. Vicoso, B. Charlesworth, Journal of Molecular Evolution 68 (2009) 576–583.

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Journal Article | Published
Author
Vicoso, BeatrizIST Austria ; Charlesworth, Brian
Abstract
In Drosophila, there is a consistent deficit of male-biased genes on the X chromosome. It has been suggested that male-biased genes may evolve from initially unbiased genes as a result of increased expression levels in males. If transcription rates are limited, a large increase in expression in the testis may be harder to achieve for single-copy X-linked genes than for autosomal genes, because they are already hypertranscribed due to dosage compensation. This hypothesis predicts that the larger the increase in expression required to make a male-biased gene, the lower the chance of this being achievable if it is located on the X chromosome. Consequently, highly expressed male-biased genes should be located on the X chromosome less often than lowly expressed male-biased genes. This pattern is observed in our analysis of publicly available data, where microarray data or EST data are used to detect male-biased genes in D. melanogaster and to measure their expression levels. This is consistent with the idea that limitations in transcription rates may prevent male-biased genes from accumulating on the X chromosome.
Publishing Year
Date Published
2009-05-01
Journal Title
Journal of Molecular Evolution
Acknowledgement
This work was funded by a Portuguese Foundation for Science and Technology scholarship to B.V., and B.C. was supported by the Royal Society
Volume
68
Issue
5
Page
576 - 583
IST-REx-ID

Cite this

Vicoso B, Charlesworth B. The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation? Journal of Molecular Evolution. 2009;68(5):576-583. doi:10.1007/s00239-009-9235-4
Vicoso, B., & Charlesworth, B. (2009). The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation? Journal of Molecular Evolution, 68(5), 576–583. https://doi.org/10.1007/s00239-009-9235-4
Vicoso, Beatriz, and Brian Charlesworth. “The Deficit of Male-Biased Genes on the D. Melanogaster X Chromosome Is Expression-Dependent: A Consequence of Dosage Compensation?” Journal of Molecular Evolution 68, no. 5 (2009): 576–83. https://doi.org/10.1007/s00239-009-9235-4.
B. Vicoso and B. Charlesworth, “The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation?,” Journal of Molecular Evolution, vol. 68, no. 5, pp. 576–583, 2009.
Vicoso B, Charlesworth B. 2009. The deficit of male-biased genes on the D. melanogaster X chromosome is expression-dependent: A consequence of dosage compensation? Journal of Molecular Evolution. 68(5), 576–583.
Vicoso, Beatriz, and Brian Charlesworth. “The Deficit of Male-Biased Genes on the D. Melanogaster X Chromosome Is Expression-Dependent: A Consequence of Dosage Compensation?” Journal of Molecular Evolution, vol. 68, no. 5, Springer, 2009, pp. 576–83, doi:10.1007/s00239-009-9235-4.

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