{"_id":"2065","page":"421 - 431","doi":"10.1017/S0016672308009804","type":"journal_article","issue":"5","publication_status":"published","publication":"Genetical Research","acknowledgement":"B.V. was supported by the Portuguese Foundation for Science and Technology, P.R.H. is supported by the Natural Environmental Research Council (UK) and B.C. was supported by the Royal Society (UK)","date_created":"2018-12-11T11:55:30Z","status":"public","author":[{"full_name":"Beatriz Vicoso","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","first_name":"Beatriz","last_name":"Vicoso"},{"last_name":"Haddrill","first_name":"Penelope","full_name":"Haddrill, Penelope R"},{"last_name":"Charlesworth","first_name":"Brian","full_name":"Charlesworth, Brian"}],"publist_id":"4972","date_updated":"2021-01-12T06:55:05Z","abstract":[{"text":"Population genetics models show that, under certain conditions, the X chromosome is expected to be under more efficient selection than the autosomes. This could lead to 'faster-X evolution', if a large proportion of mutations are fixed by positive selection, as suggested by recent studies in Drosophila. We used a multispecies approach to test this: Muller's element D, an autosomal arm, is fused to the ancestral X chromosome in Drosophila pseudoobscura and its sister species, Drosophila affinis. We tested whether the same set of genes had higher rates of non-synonymous evolution when they were X-linked (in the D. pseudoobscura/D. affinis comparison) than when they were autosomal (in Drosophila melanogaster/Drosophila yakuba). Although not significant, our results suggest this may be the case, but only for genes under particularly strong positive selection/weak purifying selection. They also suggest that genes that have become X-linked have higher levels of codon bias and slower synonymous site evolution, consistent with more effective selection on codon usage at X-linked sites.","lang":"eng"}],"volume":90,"month":"10","year":"2008","day":"01","publisher":"Cambridge University Press","quality_controlled":0,"title":"A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila","intvolume":"        90","citation":{"short":"B. Vicoso, P. Haddrill, B. Charlesworth, Genetical Research 90 (2008) 421–431.","mla":"Vicoso, Beatriz, et al. “A Multispecies Approach for Comparing Sequence Evolution of X-Linked and Autosomal Sites in Drosophila.” <i>Genetical Research</i>, vol. 90, no. 5, Cambridge University Press, 2008, pp. 421–31, doi:<a href=\"https://doi.org/10.1017/S0016672308009804\">10.1017/S0016672308009804</a>.","ieee":"B. Vicoso, P. Haddrill, and B. Charlesworth, “A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila,” <i>Genetical Research</i>, vol. 90, no. 5. Cambridge University Press, pp. 421–431, 2008.","ama":"Vicoso B, Haddrill P, Charlesworth B. A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. <i>Genetical Research</i>. 2008;90(5):421-431. doi:<a href=\"https://doi.org/10.1017/S0016672308009804\">10.1017/S0016672308009804</a>","chicago":"Vicoso, Beatriz, Penelope Haddrill, and Brian Charlesworth. “A Multispecies Approach for Comparing Sequence Evolution of X-Linked and Autosomal Sites in Drosophila.” <i>Genetical Research</i>. Cambridge University Press, 2008. <a href=\"https://doi.org/10.1017/S0016672308009804\">https://doi.org/10.1017/S0016672308009804</a>.","ista":"Vicoso B, Haddrill P, Charlesworth B. 2008. A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research. 90(5), 421–431.","apa":"Vicoso, B., Haddrill, P., &#38; Charlesworth, B. (2008). A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. <i>Genetical Research</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0016672308009804\">https://doi.org/10.1017/S0016672308009804</a>"},"extern":1,"date_published":"2008-10-01T00:00:00Z"}