--- _id: '2040' abstract: - lang: eng text: 'Development requires tissue growth as well as cell diversification. To address how these processes are coordinated, we analyzed the development of molecularly distinct domains of neural progenitors in the mouse and chick neural tube. We show that during development, these domains undergo changes in size that do not scale with changes in overall tissue size. Our data show that domain proportions are first established by opposing morphogen gradients and subsequently controlled by domain-specific regulation of differentiation rate but not differences in proliferation rate. Regulation of differentiation rate is key to maintaining domain proportions while accommodating both intra- and interspecies variations in size. Thus, the sequential control of progenitor specification and differentiation elaborates pattern without requiring that signaling gradients grow as tissues expand. ' article_number: '1254927' author: - first_name: Anna full_name: Kicheva, Anna last_name: Kicheva - first_name: Mark Tobias full_name: Bollenbach, Mark Tobias id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87 last_name: Bollenbach orcid: 0000-0003-4398-476X - first_name: Ana full_name: Ribeiro, Ana last_name: Ribeiro - first_name: Helena full_name: Pérez Valle, Helena last_name: Pérez Valle - first_name: Robin full_name: Lovell Badge, Robin last_name: Lovell Badge - first_name: Vasso full_name: Episkopou, Vasso last_name: Episkopou - first_name: James full_name: Briscoe, James last_name: Briscoe citation: ama: Kicheva A, Bollenbach MT, Ribeiro A, et al. Coordination of progenitor specification and growth in mouse and chick spinal cord. Science. 2014;345(6204). doi:10.1126/science.1254927 apa: Kicheva, A., Bollenbach, M. T., Ribeiro, A., Pérez Valle, H., Lovell Badge, R., Episkopou, V., & Briscoe, J. (2014). Coordination of progenitor specification and growth in mouse and chick spinal cord. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1254927 chicago: Kicheva, Anna, Mark Tobias Bollenbach, Ana Ribeiro, Helena Pérez Valle, Robin Lovell Badge, Vasso Episkopou, and James Briscoe. “Coordination of Progenitor Specification and Growth in Mouse and Chick Spinal Cord.” Science. American Association for the Advancement of Science, 2014. https://doi.org/10.1126/science.1254927. ieee: A. Kicheva et al., “Coordination of progenitor specification and growth in mouse and chick spinal cord,” Science, vol. 345, no. 6204. American Association for the Advancement of Science, 2014. ista: Kicheva A, Bollenbach MT, Ribeiro A, Pérez Valle H, Lovell Badge R, Episkopou V, Briscoe J. 2014. Coordination of progenitor specification and growth in mouse and chick spinal cord. Science. 345(6204), 1254927. mla: Kicheva, Anna, et al. “Coordination of Progenitor Specification and Growth in Mouse and Chick Spinal Cord.” Science, vol. 345, no. 6204, 1254927, American Association for the Advancement of Science, 2014, doi:10.1126/science.1254927. short: A. Kicheva, M.T. Bollenbach, A. Ribeiro, H. Pérez Valle, R. Lovell Badge, V. Episkopou, J. Briscoe, Science 345 (2014). date_created: 2018-12-11T11:55:22Z date_published: 2014-09-26T00:00:00Z date_updated: 2021-01-12T06:54:55Z day: '26' department: - _id: ToBo doi: 10.1126/science.1254927 intvolume: ' 345' issue: '6204' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228193/ month: '09' oa: 1 oa_version: Submitted Version publication: Science publication_status: published publisher: American Association for the Advancement of Science publist_id: '5011' quality_controlled: '1' scopus_import: 1 status: public title: Coordination of progenitor specification and growth in mouse and chick spinal cord type: journal_article user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87 volume: 345 year: '2014' ...