---
_id: '2040'
abstract:
- lang: eng
text: 'Development requires tissue growth as well as cell diversification. To address
how these processes are coordinated, we analyzed the development of molecularly
distinct domains of neural progenitors in the mouse and chick neural tube. We
show that during development, these domains undergo changes in size that do not
scale with changes in overall tissue size. Our data show that domain proportions
are first established by opposing morphogen gradients and subsequently controlled
by domain-specific regulation of differentiation rate but not differences in proliferation
rate. Regulation of differentiation rate is key to maintaining domain proportions
while accommodating both intra- and interspecies variations in size. Thus, the
sequential control of progenitor specification and differentiation elaborates
pattern without requiring that signaling gradients grow as tissues expand. '
article_number: '1254927'
author:
- first_name: Anna
full_name: Kicheva, Anna
last_name: Kicheva
- first_name: Mark Tobias
full_name: Bollenbach, Mark Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
- first_name: Ana
full_name: Ribeiro, Ana
last_name: Ribeiro
- first_name: Helena
full_name: Pérez Valle, Helena
last_name: Pérez Valle
- first_name: Robin
full_name: Lovell Badge, Robin
last_name: Lovell Badge
- first_name: Vasso
full_name: Episkopou, Vasso
last_name: Episkopou
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
citation:
ama: Kicheva A, Bollenbach MT, Ribeiro A, et al. Coordination of progenitor specification
and growth in mouse and chick spinal cord. Science. 2014;345(6204). doi:10.1126/science.1254927
apa: Kicheva, A., Bollenbach, M. T., Ribeiro, A., Pérez Valle, H., Lovell Badge,
R., Episkopou, V., & Briscoe, J. (2014). Coordination of progenitor specification
and growth in mouse and chick spinal cord. Science. American Association
for the Advancement of Science. https://doi.org/10.1126/science.1254927
chicago: Kicheva, Anna, Mark Tobias Bollenbach, Ana Ribeiro, Helena Pérez Valle,
Robin Lovell Badge, Vasso Episkopou, and James Briscoe. “Coordination of Progenitor
Specification and Growth in Mouse and Chick Spinal Cord.” Science. American
Association for the Advancement of Science, 2014. https://doi.org/10.1126/science.1254927.
ieee: A. Kicheva et al., “Coordination of progenitor specification and growth
in mouse and chick spinal cord,” Science, vol. 345, no. 6204. American
Association for the Advancement of Science, 2014.
ista: Kicheva A, Bollenbach MT, Ribeiro A, Pérez Valle H, Lovell Badge R, Episkopou
V, Briscoe J. 2014. Coordination of progenitor specification and growth in mouse
and chick spinal cord. Science. 345(6204), 1254927.
mla: Kicheva, Anna, et al. “Coordination of Progenitor Specification and Growth
in Mouse and Chick Spinal Cord.” Science, vol. 345, no. 6204, 1254927,
American Association for the Advancement of Science, 2014, doi:10.1126/science.1254927.
short: A. Kicheva, M.T. Bollenbach, A. Ribeiro, H. Pérez Valle, R. Lovell Badge,
V. Episkopou, J. Briscoe, Science 345 (2014).
date_created: 2018-12-11T11:55:22Z
date_published: 2014-09-26T00:00:00Z
date_updated: 2021-01-12T06:54:55Z
day: '26'
department:
- _id: ToBo
doi: 10.1126/science.1254927
intvolume: ' 345'
issue: '6204'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228193/
month: '09'
oa: 1
oa_version: Submitted Version
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5011'
quality_controlled: '1'
scopus_import: 1
status: public
title: Coordination of progenitor specification and growth in mouse and chick spinal
cord
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 345
year: '2014'
...