--- res: bibo_abstract: - Radial glial progenitors (RGPs) are responsible for producing nearly all neocortical neurons. To gain insight into the patterns of RGP division and neuron production, we quantitatively analyzed excitatory neuron genesis in the mouse neocortex using Mosaic Analysis with Double Markers, which provides single-cell resolution of progenitor division patterns and potential in vivo. We found that RGPs progress through a coherent program in which their proliferative potential diminishes in a predictable manner. Upon entry into the neurogenic phase, individual RGPs produce ∼8–9 neurons distributed in both deep and superficial layers, indicating a unitary output in neuronal production. Removal of OTX1, a transcription factor transiently expressed in RGPs, results in both deep- and superficial-layer neuron loss and a reduction in neuronal unit size. Moreover, ∼1/6 of neurogenic RGPs proceed to produce glia. These results suggest that progenitor behavior and histogenesis in the mammalian neocortex conform to a remarkably orderly and deterministic program.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Peng foaf_name: Gao, Peng foaf_surname: Gao - foaf_Person: foaf_givenName: Maria P foaf_name: Postiglione, Maria P foaf_surname: Postiglione foaf_workInfoHomepage: http://www.librecat.org/personId=2C67902A-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Teresa foaf_name: Krieger, Teresa foaf_surname: Krieger - foaf_Person: foaf_givenName: Luisirene foaf_name: Hernandez, Luisirene foaf_surname: Hernandez - foaf_Person: foaf_givenName: Chao foaf_name: Wang, Chao foaf_surname: Wang - foaf_Person: foaf_givenName: Zhi foaf_name: Han, Zhi foaf_surname: Han - foaf_Person: foaf_givenName: Carmen foaf_name: Streicher, Carmen foaf_surname: Streicher foaf_workInfoHomepage: http://www.librecat.org/personId=36BCB99C-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Ekaterina foaf_name: Papusheva, Ekaterina foaf_surname: Papusheva foaf_workInfoHomepage: http://www.librecat.org/personId=41DB591E-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Ryan foaf_name: Insolera, Ryan foaf_surname: Insolera - foaf_Person: foaf_givenName: Kritika foaf_name: Chugh, Kritika foaf_surname: Chugh - foaf_Person: foaf_givenName: Oren foaf_name: Kodish, Oren foaf_surname: Kodish - foaf_Person: foaf_givenName: Kun foaf_name: Huang, Kun foaf_surname: Huang - foaf_Person: foaf_givenName: Benjamin foaf_name: Simons, Benjamin foaf_surname: Simons - foaf_Person: foaf_givenName: Liqun foaf_name: Luo, Liqun foaf_surname: Luo - foaf_Person: foaf_givenName: Simon foaf_name: Hippenmeyer, Simon foaf_surname: Hippenmeyer foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-2279-1061 - foaf_Person: foaf_givenName: Song foaf_name: Shi, Song foaf_surname: Shi bibo_doi: 10.1016/j.cell.2014.10.027 bibo_issue: '4' bibo_volume: 159 dct_date: 2014^xs_gYear dct_language: eng dct_publisher: Cell Press@ dct_title: Deterministic progenitor behavior and unitary production of neurons in the neocortex@ ...