Spatial regulators for bacterial cell division self-organize into surface waves in vitro

Loose M, Fischer Friedrich E, Ries J, Kruse K, Schwille P. 2008. Spatial regulators for bacterial cell division self-organize into surface waves in vitro. Science. 320(5877), 789–792.

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Journal Article | Published
Author
Loose, MartinIST Austria ; Fischer-Friedrich, Elisabeth; Ries, Jonas ; Kruse, Karsten; Schwille, Petra
Abstract
In the bacterium Escherichia coli, the Min proteins oscillate between the cell poles to select the cell center as division site. This dynamic pattern has been proposed to arise by self-organization of these proteins, and several models have suggested a reaction-diffusion type mechanism. Here, we found that the Min proteins spontaneously formed planar surface waves on a flat membrane in vitro. The formation and maintenance of these patterns, which extended for hundreds of micrometers, required adenosine 5′-triphosphate (ATP), and they persisted for hours. We present a reaction-diffusion model of the MinD and MinE dynamics that accounts for our experimental observations and also captures the in vivo oscillations.
Publishing Year
Date Published
2008-05-09
Journal Title
Science
Acknowledgement
This work was supported by the Max-Planck-Society (M.L., P.S., E.F.).
Volume
320
Issue
5877
Page
789 - 792
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Loose M, Fischer Friedrich E, Ries J, Kruse K, Schwille P. Spatial regulators for bacterial cell division self-organize into surface waves in vitro. Science. 2008;320(5877):789-792. doi:10.1126/science.1154413
Loose, M., Fischer Friedrich, E., Ries, J., Kruse, K., & Schwille, P. (2008). Spatial regulators for bacterial cell division self-organize into surface waves in vitro. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1154413
Loose, Martin, Elisabeth Fischer Friedrich, Jonas Ries, Karsten Kruse, and Petra Schwille. “Spatial Regulators for Bacterial Cell Division Self-Organize into Surface Waves in Vitro.” Science. American Association for the Advancement of Science, 2008. https://doi.org/10.1126/science.1154413.
M. Loose, E. Fischer Friedrich, J. Ries, K. Kruse, and P. Schwille, “Spatial regulators for bacterial cell division self-organize into surface waves in vitro,” Science, vol. 320, no. 5877. American Association for the Advancement of Science, pp. 789–792, 2008.
Loose M, Fischer Friedrich E, Ries J, Kruse K, Schwille P. 2008. Spatial regulators for bacterial cell division self-organize into surface waves in vitro. Science. 320(5877), 789–792.
Loose, Martin, et al. “Spatial Regulators for Bacterial Cell Division Self-Organize into Surface Waves in Vitro.” Science, vol. 320, no. 5877, American Association for the Advancement of Science, 2008, pp. 789–92, doi:10.1126/science.1154413.

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