{"publication":"Science","_id":"1962","volume":309,"extern":1,"year":"2005","status":"public","citation":{"apa":"Hinchliffe, P., &#38; Sazanov, L. A. (2005). Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1113988\">https://doi.org/10.1126/science.1113988</a>","chicago":"Hinchliffe, Philip, and Leonid A Sazanov. “Biochemistry: Organization of Iron-Sulfur Clusters in Respiratory Complex I.” <i>Science</i>. American Association for the Advancement of Science, 2005. <a href=\"https://doi.org/10.1126/science.1113988\">https://doi.org/10.1126/science.1113988</a>.","ista":"Hinchliffe P, Sazanov LA. 2005. Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. Science. 309(5735), 771–774.","ieee":"P. Hinchliffe and L. A. Sazanov, “Biochemistry: Organization of iron-sulfur clusters in respiratory complex I,” <i>Science</i>, vol. 309, no. 5735. American Association for the Advancement of Science, pp. 771–774, 2005.","mla":"Hinchliffe, Philip, and Leonid A. Sazanov. “Biochemistry: Organization of Iron-Sulfur Clusters in Respiratory Complex I.” <i>Science</i>, vol. 309, no. 5735, American Association for the Advancement of Science, 2005, pp. 771–74, doi:<a href=\"https://doi.org/10.1126/science.1113988\">10.1126/science.1113988</a>.","short":"P. Hinchliffe, L.A. Sazanov, Science 309 (2005) 771–774.","ama":"Hinchliffe P, Sazanov LA. Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. <i>Science</i>. 2005;309(5735):771-774. doi:<a href=\"https://doi.org/10.1126/science.1113988\">10.1126/science.1113988</a>"},"day":"29","type":"journal_article","publist_id":"5122","publisher":"American Association for the Advancement of Science","issue":"5735","acknowledgement":"This work was funded by the Medical Research Council.","quality_controlled":0,"month":"07","publication_status":"published","intvolume":"       309","author":[{"last_name":"Hinchliffe","first_name":"Philip","full_name":"Hinchliffe, Philip "},{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0977-7989","last_name":"Sazanov","full_name":"Leonid Sazanov","first_name":"Leonid A"}],"doi":"10.1126/science.1113988","title":"Biochemistry: Organization of iron-sulfur clusters in respiratory complex I","date_published":"2005-07-29T00:00:00Z","abstract":[{"text":"\n\nComplex I of respiratory chains plays a central role in bioenergetics and is implicated in many human neurodegenerative diseases. An understanding of its mechanism requires a knowledge of the organization of redox centers. The arrangement of iron-sulfur clusters in the hydrophilic domain of complex I from Thermus thermophilus has been determined with the use of x-ray crystallography. One binuclear and six tetranuclear clusters are arranged, maximally 14 angstroms apart, in an 84-angstrom-long electron transfer chain. The binuclear cluster N1a and the tetranuclear cluster N7 are not in this pathway. Cluster N1a may play a role in the prevention of oxidative damage. The structure provides a framework for the interpretation of the large amounts of data accumulated on complex I.","lang":"eng"}],"date_created":"2018-12-11T11:54:56Z","page":"771 - 774","date_updated":"2021-01-12T06:54:22Z"}