{"main_file_link":[{"url":"https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2894%2901109-5","open_access":"1"}],"publication_identifier":{"issn":["0014-5793"]},"date_published":"1994-11-28T00:00:00Z","day":"28","status":"public","publication":"FEBS Letters","external_id":{"pmid":["7982481"]},"quality_controlled":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","issue":"2","language":[{"iso":"eng"}],"publisher":"Elsevier","abstract":[{"lang":"eng","text":"The respiratory burst induced by phorbol myristate acetate in mouse macrophages was inhibited by ultra-low doses (10-15 -10-13 M) of an opioid peptide [d-Ala2] methionine enkephalinamide. The effect disappeared at concentrations above and below this range. The inhibition approached 50% and was statistically significant (P &lt; 0.001). Increasing the time of the opioid incubation with cells brought about a shift in the maximal effect to lower concentrations of the opioid (from 10-13 to 5 · 10-15 M) and led to a decrease in the value of the effect, fully in accord with the previously proposed adaptation mechanism of the action of ultra-low doses."}],"publist_id":"5133","citation":{"chicago":"Efanov, Alexander, Aleksei Koshkin, Leonid A Sazanov, O I Borodulina, Sergei Varfolomeev, and Sergei Zaǐtsev. “Inhibition of the Respiratory Burst in Mouse Macrophages by Ultra-Low Doses of an Opioid Peptide Is Consistent with a Possible Adaptation Mechanism.” <i>FEBS Letters</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0014-5793(94)01109-5\">https://doi.org/10.1016/0014-5793(94)01109-5</a>.","ieee":"A. Efanov, A. Koshkin, L. A. Sazanov, O. I. Borodulina, S. Varfolomeev, and S. Zaǐtsev, “Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism,” <i>FEBS Letters</i>, vol. 355, no. 2. Elsevier, pp. 114–116, 1994.","ama":"Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. <i>FEBS Letters</i>. 1994;355(2):114-116. doi:<a href=\"https://doi.org/10.1016/0014-5793(94)01109-5\">10.1016/0014-5793(94)01109-5</a>","short":"A. Efanov, A. Koshkin, L.A. Sazanov, O.I. Borodulina, S. Varfolomeev, S. Zaǐtsev, FEBS Letters 355 (1994) 114–116.","apa":"Efanov, A., Koshkin, A., Sazanov, L. A., Borodulina, O. I., Varfolomeev, S., &#38; Zaǐtsev, S. (1994). Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. <i>FEBS Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0014-5793(94)01109-5\">https://doi.org/10.1016/0014-5793(94)01109-5</a>","ista":"Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. 1994. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. FEBS Letters. 355(2), 114–116.","mla":"Efanov, Alexander, et al. “Inhibition of the Respiratory Burst in Mouse Macrophages by Ultra-Low Doses of an Opioid Peptide Is Consistent with a Possible Adaptation Mechanism.” <i>FEBS Letters</i>, vol. 355, no. 2, Elsevier, 1994, pp. 114–16, doi:<a href=\"https://doi.org/10.1016/0014-5793(94)01109-5\">10.1016/0014-5793(94)01109-5</a>."},"doi":"10.1016/0014-5793(94)01109-5","author":[{"first_name":"Alexander","last_name":"Efanov","full_name":"Efanov, Alexander"},{"full_name":"Koshkin, Aleksei","last_name":"Koshkin","first_name":"Aleksei"},{"first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","last_name":"Sazanov","full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989"},{"full_name":"Borodulina, O I","last_name":"Borodulina","first_name":"O I"},{"first_name":"Sergei","full_name":"Varfolomeev, Sergei","last_name":"Varfolomeev"},{"first_name":"Sergei","last_name":"Zaǐtsev","full_name":"Zaǐtsev, Sergei"}],"year":"1994","type":"journal_article","date_updated":"2022-06-09T12:58:57Z","month":"11","page":"114 - 116","volume":355,"date_created":"2018-12-11T11:54:53Z","_id":"1953","title":"Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism","intvolume":"       355","extern":"1","pmid":1,"publication_status":"published","oa_version":"Published Version","oa":1,"article_type":"original"}