{"publication":"Nanotechnology","date_published":"2014-03-28T00:00:00Z","day":"28","status":"public","citation":{"mla":"Lamprecht, Constanze, et al. “A Single-Molecule Approach to Explore Binding Uptake and Transport of Cancer Cell Targeting Nanotubes.” <i>Nanotechnology</i>, vol. 25, no. 12, 125704, IOP Publishing, 2014, doi:<a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">10.1088/0957-4484/25/12/125704</a>.","ista":"Lamprecht C, Plochberger B, Ruprecht V, Wieser S, Rankl C, Heister E, Unterauer B, Brameshuber M, Danzberger J, Lukanov P, Flahaut E, Schütz G, Hinterdorfer P, Ebner A. 2014. A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. Nanotechnology. 25(12), 125704.","short":"C. Lamprecht, B. Plochberger, V. Ruprecht, S. Wieser, C. Rankl, E. Heister, B. Unterauer, M. Brameshuber, J. Danzberger, P. Lukanov, E. Flahaut, G. Schütz, P. Hinterdorfer, A. Ebner, Nanotechnology 25 (2014).","apa":"Lamprecht, C., Plochberger, B., Ruprecht, V., Wieser, S., Rankl, C., Heister, E., … Ebner, A. (2014). A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. <i>Nanotechnology</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">https://doi.org/10.1088/0957-4484/25/12/125704</a>","ieee":"C. Lamprecht <i>et al.</i>, “A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes,” <i>Nanotechnology</i>, vol. 25, no. 12. IOP Publishing, 2014.","ama":"Lamprecht C, Plochberger B, Ruprecht V, et al. A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. <i>Nanotechnology</i>. 2014;25(12). doi:<a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">10.1088/0957-4484/25/12/125704</a>","chicago":"Lamprecht, Constanze, Birgit Plochberger, Verena Ruprecht, Stefan Wieser, Christian Rankl, Elena Heister, Barbara Unterauer, et al. “A Single-Molecule Approach to Explore Binding Uptake and Transport of Cancer Cell Targeting Nanotubes.” <i>Nanotechnology</i>. IOP Publishing, 2014. <a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">https://doi.org/10.1088/0957-4484/25/12/125704</a>."},"doi":"10.1088/0957-4484/25/12/125704","scopus_import":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2020-07-14T12:45:21Z","abstract":[{"text":"In the past decade carbon nanotubes (CNTs) have been widely studied as a potential drug-delivery system, especially with functionality for cellular targeting. Yet, little is known about the actual process of docking to cell receptors and transport dynamics after internalization. Here we performed single-particle studies of folic acid (FA) mediated CNT binding to human carcinoma cells and their transport inside the cytosol. In particular, we employed molecular recognition force spectroscopy, an atomic force microscopy based method, to visualize and quantify docking of FA functionalized CNTs to FA binding receptors in terms of binding probability and binding force. We then traced individual fluorescently labeled, FA functionalized CNTs after specific uptake, and created a dynamic 'roadmap' that clearly showed trajectories of directed diffusion and areas of nanotube confinement in the cytosol. Our results demonstrate the potential of a single-molecule approach for investigation of drug-delivery vehicles and their targeting capacity.","lang":"eng"}],"publist_id":"5169","publisher":"IOP Publishing","article_processing_charge":"No","language":[{"iso":"eng"}],"issue":"12","date_created":"2018-12-11T11:54:45Z","month":"03","date_updated":"2021-01-12T06:54:07Z","volume":25,"_id":"1925","title":"A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes","department":[{"_id":"CaHe"},{"_id":"MiSi"}],"author":[{"first_name":"Constanze","last_name":"Lamprecht","full_name":"Lamprecht, Constanze"},{"first_name":"Birgit","full_name":"Plochberger, Birgit","last_name":"Plochberger"},{"last_name":"Ruprecht","full_name":"Ruprecht, Verena","id":"4D71A03A-F248-11E8-B48F-1D18A9856A87","first_name":"Verena","orcid":"0000-0003-4088-8633"},{"first_name":"Stefan","id":"355AA5A0-F248-11E8-B48F-1D18A9856A87","full_name":"Wieser, Stefan","last_name":"Wieser","orcid":"0000-0002-2670-2217"},{"last_name":"Rankl","full_name":"Rankl, Christian","first_name":"Christian"},{"first_name":"Elena","full_name":"Heister, Elena","last_name":"Heister"},{"first_name":"Barbara","last_name":"Unterauer","full_name":"Unterauer, Barbara"},{"last_name":"Brameshuber","full_name":"Brameshuber, Mario","first_name":"Mario"},{"full_name":"Danzberger, Jürgen","last_name":"Danzberger","first_name":"Jürgen"},{"full_name":"Lukanov, Petar","last_name":"Lukanov","first_name":"Petar"},{"last_name":"Flahaut","full_name":"Flahaut, Emmanuel","first_name":"Emmanuel"},{"full_name":"Schütz, Gerhard","last_name":"Schütz","first_name":"Gerhard"},{"last_name":"Hinterdorfer","full_name":"Hinterdorfer, Peter","first_name":"Peter"},{"full_name":"Ebner, Andreas","last_name":"Ebner","first_name":"Andreas"}],"ddc":["570"],"year":"2014","article_number":"125704","type":"journal_article","oa_version":"Submitted Version","oa":1,"publication_status":"published","article_type":"original","acknowledgement":"This work was supported by EC grant Marie Curie RTN-CT-2006-035616, CARBIO 'Carbon nanotubes for biomedical applications' and Austrian FFG grant mnt-era.net 823980, 'IntelliTip'.\r\n","file":[{"access_level":"open_access","checksum":"df4e03d225a19179e7790f6d87a12332","file_size":3804152,"date_updated":"2020-07-14T12:45:21Z","creator":"dernst","date_created":"2020-05-15T09:21:19Z","content_type":"application/pdf","file_id":"7856","relation":"main_file","file_name":"2014_Nanotechnology_Lamprecht.pdf"}],"intvolume":"        25","has_accepted_license":"1"}