Adaptive response and enlargement of dynamic range

T. Friedlander, N. Brenner, Mathematical Biosciences and Engineering 8 (2011) 515–526.


Journal Article | Published
Author
Abstract
Many membrane channels and receptors exhibit adaptive, or desensitized, response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation. Adaptive response is thought to be related to various cellular functions such as homeostasis and enlargement of dynamic range by background compensation. Here we study the quantitative relation between adaptive response and background compensation within a modeling framework. We show that any particular type of adaptive response is neither sufficient nor necessary for adaptive enlargement of dynamic range. In particular a precise adaptive response, where system activity is maintained at a constant level at steady state, does not ensure a large dynamic range neither in input signal nor in system output. A general mechanism for input dynamic range enlargement can come about from the activity-dependent modulation of protein responsiveness by multiple biochemical modification, regardless of the type of adaptive response it induces. Therefore hierarchical biochemical processes such as methylation and phosphorylation are natural candidates to induce this property in signaling systems.
Publishing Year
Date Published
2011-04-02
Journal Title
Mathematical Biosciences and Engineering
Volume
8
Issue
2
Page
515 - 526
IST-REx-ID

Cite this

Friedlander T, Brenner N. Adaptive response and enlargement of dynamic range. Mathematical Biosciences and Engineering. 2011;8(2):515-526. doi:10.3934/mbe.2011.8.515
Friedlander, T., & Brenner, N. (2011). Adaptive response and enlargement of dynamic range. Mathematical Biosciences and Engineering, 8(2), 515–526. https://doi.org/10.3934/mbe.2011.8.515
Friedlander, Tamar, and Naama Brenner. “Adaptive Response and Enlargement of Dynamic Range.” Mathematical Biosciences and Engineering 8, no. 2 (2011): 515–26. https://doi.org/10.3934/mbe.2011.8.515.
T. Friedlander and N. Brenner, “Adaptive response and enlargement of dynamic range,” Mathematical Biosciences and Engineering, vol. 8, no. 2, pp. 515–526, 2011.
Friedlander T, Brenner N. 2011. Adaptive response and enlargement of dynamic range. Mathematical Biosciences and Engineering. 8(2), 515–526.
Friedlander, Tamar, and Naama Brenner. “Adaptive Response and Enlargement of Dynamic Range.” Mathematical Biosciences and Engineering, vol. 8, no. 2, Arizona State University, 2011, pp. 515–26, doi:10.3934/mbe.2011.8.515.

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