---
_id: '1725'
abstract:
- lang: eng
text: The spatial organization of cell fates during development involves the interpretation
of morphogen gradients by cellular signaling cascades and transcriptional networks.
Recent studies use biophysical models, genetics, and quantitative imaging to unravel
how tissue-level morphogen behavior arises from subcellular events. Moreover,
data from several systems show that morphogen gradients, downstream signaling,
and the activity of cell-intrinsic transcriptional networks change dynamically
during pattern formation. Studies from Drosophila and now also vertebrates suggest
that transcriptional network dynamics are central to the generation of gene expression
patterns. Together, this leads to the view that pattern formation is an emergent
behavior that results from the coordination of events occurring across molecular,
cellular, and tissue scales. The development of novel approaches to study this
complex process remains a challenge.
acknowledgement: 'Funding provided by the Medical Research Council (UK). '
author:
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Michael
full_name: Cohen, Michael H
last_name: Cohen
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
citation:
ama: 'Kicheva A, Cohen M, Briscoe J. Developmental pattern formation: Insights from
physics and biology. Science. 2012;338(6104):210-212. doi:10.1126/science.1225182'
apa: 'Kicheva, A., Cohen, M., & Briscoe, J. (2012). Developmental pattern formation:
Insights from physics and biology. Science. American Association for the
Advancement of Science. https://doi.org/10.1126/science.1225182'
chicago: 'Kicheva, Anna, Michael Cohen, and James Briscoe. “Developmental Pattern
Formation: Insights from Physics and Biology.” Science. American Association
for the Advancement of Science, 2012. https://doi.org/10.1126/science.1225182.'
ieee: 'A. Kicheva, M. Cohen, and J. Briscoe, “Developmental pattern formation: Insights
from physics and biology,” Science, vol. 338, no. 6104. American Association
for the Advancement of Science, pp. 210–212, 2012.'
ista: 'Kicheva A, Cohen M, Briscoe J. 2012. Developmental pattern formation: Insights
from physics and biology. Science. 338(6104), 210–212.'
mla: 'Kicheva, Anna, et al. “Developmental Pattern Formation: Insights from Physics
and Biology.” Science, vol. 338, no. 6104, American Association for the
Advancement of Science, 2012, pp. 210–12, doi:10.1126/science.1225182.'
short: A. Kicheva, M. Cohen, J. Briscoe, Science 338 (2012) 210–212.
date_created: 2018-12-11T11:53:40Z
date_published: 2012-10-12T00:00:00Z
date_updated: 2021-01-12T06:52:47Z
day: '12'
doi: 10.1126/science.1225182
extern: 1
intvolume: ' 338'
issue: '6104'
month: '10'
page: 210 - 212
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5404'
quality_controlled: 0
status: public
title: 'Developmental pattern formation: Insights from physics and biology'
type: journal_article
volume: 338
year: '2012'
...