--- _id: '1725' abstract: - lang: eng text: The spatial organization of cell fates during development involves the interpretation of morphogen gradients by cellular signaling cascades and transcriptional networks. Recent studies use biophysical models, genetics, and quantitative imaging to unravel how tissue-level morphogen behavior arises from subcellular events. Moreover, data from several systems show that morphogen gradients, downstream signaling, and the activity of cell-intrinsic transcriptional networks change dynamically during pattern formation. Studies from Drosophila and now also vertebrates suggest that transcriptional network dynamics are central to the generation of gene expression patterns. Together, this leads to the view that pattern formation is an emergent behavior that results from the coordination of events occurring across molecular, cellular, and tissue scales. The development of novel approaches to study this complex process remains a challenge. acknowledgement: 'Funding provided by the Medical Research Council (UK). ' author: - first_name: Anna full_name: Anna Kicheva id: 3959A2A0-F248-11E8-B48F-1D18A9856A87 last_name: Kicheva orcid: 0000-0003-4509-4998 - first_name: Michael full_name: Cohen, Michael H last_name: Cohen - first_name: James full_name: Briscoe, James last_name: Briscoe citation: ama: 'Kicheva A, Cohen M, Briscoe J. Developmental pattern formation: Insights from physics and biology. Science. 2012;338(6104):210-212. doi:10.1126/science.1225182' apa: 'Kicheva, A., Cohen, M., & Briscoe, J. (2012). Developmental pattern formation: Insights from physics and biology. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1225182' chicago: 'Kicheva, Anna, Michael Cohen, and James Briscoe. “Developmental Pattern Formation: Insights from Physics and Biology.” Science. American Association for the Advancement of Science, 2012. https://doi.org/10.1126/science.1225182.' ieee: 'A. Kicheva, M. Cohen, and J. Briscoe, “Developmental pattern formation: Insights from physics and biology,” Science, vol. 338, no. 6104. American Association for the Advancement of Science, pp. 210–212, 2012.' ista: 'Kicheva A, Cohen M, Briscoe J. 2012. Developmental pattern formation: Insights from physics and biology. Science. 338(6104), 210–212.' mla: 'Kicheva, Anna, et al. “Developmental Pattern Formation: Insights from Physics and Biology.” Science, vol. 338, no. 6104, American Association for the Advancement of Science, 2012, pp. 210–12, doi:10.1126/science.1225182.' short: A. Kicheva, M. Cohen, J. Briscoe, Science 338 (2012) 210–212. date_created: 2018-12-11T11:53:40Z date_published: 2012-10-12T00:00:00Z date_updated: 2021-01-12T06:52:47Z day: '12' doi: 10.1126/science.1225182 extern: 1 intvolume: ' 338' issue: '6104' month: '10' page: 210 - 212 publication: Science publication_status: published publisher: American Association for the Advancement of Science publist_id: '5404' quality_controlled: 0 status: public title: 'Developmental pattern formation: Insights from physics and biology' type: journal_article volume: 338 year: '2012' ...