Dynamics of anisotropic tissue growth

T. Bittig, O. Wartlick, A. Kicheva, M. González Gaitárr, F. Julicher, New Journal of Physics 10 (2008).

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Journal Article | Published
Author
Bittig, Thomas; Wartlick, Ortrud; Kicheva, AnnaIST Austria; González-Gaitárr, Marcos; Julicher, Frank
Abstract
We study the mechanics of tissue growth via cell division and cell death (apoptosis). The rearrangements of cells can on large scales and times be captured by a continuum theory which describes the tissue as an effective viscous material with active stresses generated by cell division. We study the effects of anisotropies of cell division on cell rearrangements and show that average cellular trajectories exhibit anisotropic scaling behaviors. If cell division and apoptosis balance, there is no net growth, but for anisotropic cell division the tissue undergoes spontaneous shear deformations. Our description is relevant for the study of developing tissues such as the imaginal disks of the fruit fly Drosophila melanogaster, which grow anisotropically.
Publishing Year
Date Published
2008-06-03
Journal Title
New Journal of Physics
Volume
10
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Bittig T, Wartlick O, Kicheva A, González Gaitárr M, Julicher F. Dynamics of anisotropic tissue growth. New Journal of Physics. 2008;10. doi:10.1088/1367-2630/10/6/063001
Bittig, T., Wartlick, O., Kicheva, A., González Gaitárr, M., & Julicher, F. (2008). Dynamics of anisotropic tissue growth. New Journal of Physics, 10. https://doi.org/10.1088/1367-2630/10/6/063001
Bittig, Thomas, Ortrud Wartlick, Anna Kicheva, Marcos González Gaitárr, and Frank Julicher. “Dynamics of Anisotropic Tissue Growth.” New Journal of Physics 10 (2008). https://doi.org/10.1088/1367-2630/10/6/063001.
T. Bittig, O. Wartlick, A. Kicheva, M. González Gaitárr, and F. Julicher, “Dynamics of anisotropic tissue growth,” New Journal of Physics, vol. 10, 2008.
Bittig T, Wartlick O, Kicheva A, González Gaitárr M, Julicher F. 2008. Dynamics of anisotropic tissue growth. New Journal of Physics. 10.
Bittig, Thomas, et al. “Dynamics of Anisotropic Tissue Growth.” New Journal of Physics, vol. 10, IOP Publishing Ltd., 2008, doi:10.1088/1367-2630/10/6/063001.

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